FcRn plays a central role in regulating the half-life of IgG antibodies and albumin, making it a critical target in both antibody engineering and autoimmune disease therapy. This article explores the biology of FcRn, the use of HMEC-1 cells for measuring FcRn-mediated IgG recycling, and the assays used to support the development of next-generation [...]
It’s Congo’s 17th outbreak, with a toll that has eclipsed that of the country’s 2018-2020 outbreak when 2,299 deaths out of 3,481 cases were recorded. The latest data shows 101 new cases and 33 deaths reported in the previous 24 hours. Over 1,000 people have recovered, while 730 remain in hospitals or isolation. The [...]
At a moment when AI is forcing a fundamental rethink of how work gets done, the life sciences industry is grappling with a deeper question: what role should human creativity play in an increasingly automated world? For Mike Guarino, CEO of EVERSANA INTOUCH, the answer lies not in replacement, but in amplification. He describes [...]
A simple blood test that detects chemical changes in DNA identified more than 90% of stage 2-4 lung cancers in an early study, without relying on costly DNA sequencing. Researchers at Tel Aviv University and collaborating medical centers have developed a blood test for lung cancer that analyzes chemical patterns on fragments of DNA circulating in [...]
Professor Joseph C. Wu of Stanford University explains how stem cells, human-relevant models and AI are helping researchers predict which drug candidates are most likely to succeed before clinical trials. Researchers now have access to technologies that were unimaginable mere decades ago, from genome editing to patient-derived organoids. Despite these advances, many promising drug candidates [...]
Vaccines that do not need to be kept cool in a fridge have been successfully trialed in patients for the first time, say UK scientists. Currently, most vaccines need to be refrigerated or frozen – but around half are wasted each year, mainly because they become unusable after getting too hot or too cold. [...]
A mushroom sold in markets and served in restaurants in Southwest China has an unusual warning attached to it: cook it thoroughly, or you may start seeing tiny people. For decades, people have reported extraordinarily detailed hallucinations after eating certain wild mushrooms, describing dozens or even hundreds of miniature humanlike figures walking across tables, [...]
Artificial Intelligence has been used to design brand new viruses that are fully functional and can replicate in the laboratory, say US researchers. It is the first time whole genomes have been successfully designed by AI. The resulting 16 novel viruses were created to infect bacteria and pose no threat to people. The breakthrough [...]
This book explores the revolutionary potential of atomically precise manufacturing technologies to transform global healthcare, as well as practically every other sector across society. This forward-thinking volume examines how envisaged Factory@Home systems might enable the cost-effective domestic fabrication of (among myriad consumer products, including nutritious gourmet foods) advanced autonomous nanomedical devices that have the capacity to address most [...]
If the Phase I trial is successful, Moderna plans to quickly initiate Phase II and Phase III trials of its Ebola vaccine. Moderna has initiated a Phase I trial of its mRNA Ebola vaccine for the Bundibugyo variant, just as Africa is readying itself for research. The first-in-human Phase I trial (NCT07737717), which will [...]
