Brigham and Women's Hospital's TIMI Study Group reports that in patients with prior ischemic stroke, very low achieved LDL-cholesterol correlated with fewer major adverse cardiovascular events and fewer recurrent strokes, without an apparent increase in hemorrhagic stroke. Study background and patient population Patients with prior ischemic stroke face a high risk for recurrence and [...]
University of Tokyo researchers have created a powerful new microscope that captures both forward- and back-scattered light at once, letting scientists see everything from large cell structures to tiny nanoscale particles in a single shot. Researchers at the University of Tokyo have developed a new type of microscope that can detect signals over an intensity range [...]
Researchers in Japan found that although the Alzheimer’s drug lecanemab successfully removes amyloid plaques from the brain, it does not restore the brain’s waste-clearing system within the first few months of treatment. The study suggests that by the time symptoms appear, damage to nerve cells and the glymphatic system is already well established, making short-term recovery [...]
Colorectal cancer is striking younger adults at alarming rates, driven by lifestyle and genetic factors. Colorectal cancer (CRC) develops when abnormal cells grow uncontrollably in the colon or rectum, forming tumors that can eventually invade nearby tissues or spread to other parts of the body. It typically begins as small, benign growths called polyps, [...]
Scientists have discovered that the body can naturally dull pain through its own localized “benzodiazepine-like” peptides. A groundbreaking study led by a University of Leeds scientist has unveiled new insights into how the body manages pain, offering a potential path toward treating long-term pain without relying on addictive opioids. Professor Nikita Gamper, from the School of [...]
Three new Cochrane reviews find evidence that GLP-1 drugs lead to clinically meaningful weight loss, though industry-funded studies raise concerns. Three new reviews from Cochrane have found that GLP-1 medications can lead to significant weight loss, though questions remain about the influence of industry-funded research. Commissioned by the World Health Organization (WHO), these reviews [...]
Researchers have developed an innovative and versatile system designed for a new generation of short-pulse lasers. Lasers that produce extremely short bursts of light are known for their remarkable precision, making them indispensable tools in manufacturing, medical technology, and scientific research. However, creating short-pulse lasers that are both powerful and efficient typically requires large, [...]
Cancer immunotherapy, which uses drugs that stimulate the body’s immune cells to attack tumors, is a promising approach to treating many types of cancer. However, it doesn’t work well for some tumors, including ovarian cancer. To elicit a better response, MIT researchers have designed new nanoparticles that can deliver an immune-stimulating molecule called IL-12 [...]
By restructuring a common chemotherapy drug, scientists increased its potency by 20,000 times. In a significant step forward for cancer therapy, researchers at Northwestern University have redesigned the molecular structure of a well-known chemotherapy drug, greatly increasing its solubility, effectiveness, and safety. For this study, the scientists created the drug entirely from scratch as a spherical [...]
Cardiovascular disease continues to be the leading cause of death worldwide. But advances in heart-failure therapeutics have stalled, largely due to the difficulty of delivering treatments at the cellular level. Now, a UC Berkeley-led team of researchers may have solved this delivery bottleneck, potentially opening the door to novel, lifesaving treatments. At the core [...]
