The new platform helped UC San Diego scientists synthesize 32 potential multi-target cancer drugs. Scientists at UC San Diego have developed a machine learning algorithm to simulate the time-consuming chemistry involved in the earliest phases of drug discovery, which could significantly streamline the process and open doors for never-before-seen treatments. Identifying candidate drugs for further optimization [...]

An international team, led by researchers from Australia, have developed a system using nanotechnology that could allow people with diabetes to take oral insulin in the future. The researchers say the new insulin could be eaten by taking a tablet or even embedded within a piece of chocolate. The new nano carrier, tested in [...]

Researchers at Johns Hopkins Children’s Center express that the study results offer a sense of reassurance, instilling “guarded optimism” regarding the developmental outcomes of young children who have been exposed to restrictions stemming from the pandemic. A study conducted by the Johns Hopkins Children’s Center has found that infants and children up to the [...]

Researchers have discovered the process by which dietary choline crosses the blood-brain barrier. This breakthrough has potential applications in enhancing drug delivery to the brain for treating neurological disorders. A researcher from the University of Queensland has identified molecular doorways that could facilitate the delivery of drugs to the brain for treating neurological disorders. Dr. Rosemary [...]

Nucleic acid-based medications such as mRNA vaccines offer tremendous potential for medicine and are opening up new therapeutic approaches. These active ingredients must be enclosed inside nanoparticles to ensure that they get to where they are needed inside the body's cells. The Fraunhofer Institute for Production Systems and Design Technology IPK and FDX Fluid [...]

By providing plausible label maps for one medical image, the Tyche machine-learning model could help clinicians and researchers capture crucial information. In biomedicine, segmentation involves annotating pixels from an important structure in a medical image, like an organ or cell. Artificial intelligence models can help clinicians by highlighting pixels that may show signs of [...]

MoTrPAC examined the molecular effects of exercise on 2,600 volunteers, incorporating factors like age, race, and gender diversity. Building upon research in rats, MoTrPAC discovered over 35,000 biological molecules responding to endurance exercise and widespread gender differences in responses. Initial findings from MoTrPAC underscore the importance of including both sexes in exercise research to [...]

A study in JAMA Oncology reveals that MyProstateScore 2.0, a new urine test analyzing 18 genes, surpasses PSA in detecting significant prostate cancers and could reduce unnecessary biopsies by up to 42%. A new urine test that measures 18 genes associated with prostate cancer provides higher accuracy for detecting clinically significant cancers than PSA and other existing biomarker [...]

This uncommon process is more frequently observed in neurodegenerative diseases and could offer insights into disease mechanisms. According to a new study published in PLOS Biology by Kim Hai-Man Chow and colleagues from the Chinese University of Hong Kong, neurons in the brain that re-enter the cell cycle after mitosis are prone to quick senescence, a [...]

Researchers at UC San Diego have utilized advanced imaging techniques to explore the metabolic processes behind Alzheimer’s disease, leading to potential new strategies for treatment. Alzheimer’s disease, the most common type of dementia, significantly impairs memory, thinking, and behavior, affecting over 50 million people globally each year. Projections suggest that this number will triple by [...]