Research led by the University of Pennsylvania, Philadelphia, has used siRNA-based silencing of protein cyclophilin A (CyPA) to reduce tumor burden and extend the lives of patients with multiple myeloma. In the paper, "In vivo bone marrow microenvironment siRNA delivery using lipid–polymer nanoparticles for multiple myeloma therapy," published in PNAS, the researchers detail a targeted nanoparticle platform [...]
A new study reveals that the SARS-CoV-2 virus infects cells by binding a single virus to a single ACE2 receptor, contrary to previous theories. This was discovered through super-resolution microscopy which also showed a low density of ACE2 receptors on cell membranes, challenging the possibility of a virus particle binding to multiple receptors simultaneously. This new understanding [...]
Multiple myeloma is an incurable bone marrow cancer that kills over 100,000 people every year. Known for its quick and deadly spread, this disease is one of the most challenging to address. As these cancer cells move through different parts of the body, they mutate, outpacing possible treatments. People diagnosed with severe multiple myeloma [...]
In a collaboration with Groningen University, Professor Jørgen Kjems and his research group at Aarhus University have achieved a remarkable breakthrough in developing tiny nano-sized pores that can contribute to better possibilities for, among other things, detecting diseases at an earlier stage. Their work, recently published in the scientific journal ACS Nano ("Specific Detection of Proteins [...]
A new study led by researchers at the University of Oxford’s Department of Computer Science has found that, between 2021 and 2022, COVID-19 was a leading cause of death in children and young people in the United States, ranking eighth overall. The results demonstrate that pharmaceutical and public health interventions should continue to be applied to [...]
A groundbreaking machine-learning study has unmasked the best drug combinations to prevent COVID-19 from coming back after an initial infection. It turns out these combos are not the same for every patient. Using real-world data from a hospital in China, the UC Riverside-led study found that individual characteristics, including age, weight, and additional illness [...]
Researchers have developed coherence maps, a technique to visualize quantum mechanics and understand the mechanisms underpinning photosynthesis. The maps elucidate the complex energy transfer process in photosynthesizing bacteria, providing a clear picture of how sunlight energy is channeled from the outer to the inner molecular ring of the light-harvesting complex. Systems obeying quantum mechanics are [...]
Researchers have discovered viruses such as SARS-CoV-2 can cause brain cells to fuse, initiating malfunctions that lead to chronic neurological symptoms. Scientists at The University of Queensland have discovered viruses such as SARS-CoV-2 can cause brain cells to fuse, initiating malfunctions that lead to chronic neurological symptoms. Professor Massimo Hilliard and Dr. Ramon Martinez-Marmol from the [...]
The fact that our immune systems capture and destroy nanoparticles and the drugs they carry has been a problem in the field of nanomedicine for some time. But, in the fight against cancer, researchers are now attempting to exploit this problem to their advantage. Researchers around the world are seeking to identify techniques that [...]
Researchers from the University of Bern, Inselspital, University Hospital Bern, and the University of Connecticut have made a significant breakthrough in the fight against cancer. They identified a previously unknown weak point of prostate cancer cells. This could also lead to entirely new therapeutic approaches for other types of cancer. Prostate cancer is the [...]
