If the Phase I trial is successful, Moderna plans to quickly initiate Phase II and Phase III trials of its Ebola vaccine. Moderna has initiated a Phase I trial of its mRNA Ebola vaccine for the Bundibugyo variant, just as Africa is readying itself for research. The first-in-human Phase I trial (NCT07737717), which will [...]
Summary: Researchers introduced a highly reproducible three-dimensional human brain tissue model capable of replicating complex neurodegenerative processes in Alzheimer’s disease. Developed over nine years using human stem cells, the self-organizing tissue spheroids integrate functional neurons, astrocytes, and microglial immune cells into micro-architectures the size of half a pinhead. The engineered tissue model faithfully expresses key [...]
Chemotherapy may kill most ovarian cancer cells, but the few that survive can turn dangerously active. By releasing fructose, they may help nearby tumor cells break free and spread. Researchers at The Wistar Institute uncovered this unexpected chain reaction while studying treatment-induced cellular senescence, a state in which damaged cancer cells stop dividing but [...]
Virus reactivations by SARS-CoV-2 could worsen initial symptoms and increase risk of Long Covid. Early in the COVID-19 pandemic, scientists noticed that a SARS-CoV-2 infection can “wake up” other, dormant viruses already present in the body. A study out today in Nature extends those and subsequent observations, documenting viral reactivation for a cohort of more than 1000 [...]
A single-cell study reveals major changes in immune cells, genome organization, and gene regulation within the aging human hippocampus, offering important insights into brain aging and dementias associated with age. Between roughly ages 50 and 75, the cellular landscape of the human hippocampus begins to shift. Immune cells change, the genome’s physical organization weakens, [...]
Online Sellers other than Amazon, Routledge, and IOPP Indigo Global Health Care Equivalency in the Age of Nanotechnology, Nanomedicine and Artifcial Intelligence Global Health Care Equivalency In The Age Of Nanotechnology, Nanomedicine And Artificial Intelligence Book By Frank J Boehm, (Hardcover) | Indigo Molecular Manufacturing: The Future of Nanomedicine Molecular Manufacturing: The Future Of [...]
Researchers mapped where DNA first opens and how a helicase gate may release one strand as genome copying begins. Before a cell can divide, it must open its tightly wound DNA and begin copying the entire genome. Researchers at the MRC Laboratory of Medical Sciences (LMS) and collaborating institutions have now traced this process to one [...]
Limiting the daily eating window may provide brain benefits beyond those associated with weight loss. Eating within a shorter daily window may provide cognitive benefits beyond those associated with weight loss alone, according to results from a small clinical trial. The pilot study followed older women with overweight or obesity during a weight-loss program [...]
Summary: A new study demonstrates that primary brain tumors (gliomas) are particularly receptive to targeted drug delivery using focused ultrasound (FUS) combined with microbubbles. The team developed a high-resolution MRI protocol to track blood-brain barrier (BBB) opening and molecular transport inside the tumor microenvironment. The research allays long-standing clinical concerns that mutated tumor vasculature would [...]
AI tools are becoming increasingly common in early drug discovery, allowing scientists to analyse data and navigate large volumes of research. However, according to Dr Raminderpal Singh, turning that potential into consistent scientific workflows is far from straightforward. Artificial intelligence (AI) is becoming an increasingly prominent part of drug discovery, particularly in early-stage research where [...]
