What if you could take a picture of every gene inside a living organism—not with light, but with DNA itself? Scientists at the University of Chicago have pioneered a revolutionary imaging technique called volumetric DNA microscopy. It builds intricate 3D maps of genetic material by tagging and tracking molecular interactions, creating never-before-seen views inside organisms like zebrafish embryos. [...]

Scientists at EMBL have captured how human chromosomes fold into their signature rod shape during cell division, using a groundbreaking method called LoopTrace. By observing overlapping DNA loops forming in high resolution, they revealed that large loops form first, followed by nested smaller loops, all repelling each other into compact structures. This new insight not only [...]

H5N1 influenza is evolving rapidly, weakening the effectiveness of existing antibodies and increasing its potential threat to humans. Scientists at UNC Charlotte and MIT used high-performance computational modeling to analyze thousands of viral protein-antibody interactions, revealing a decline in immune response effectiveness. Their research suggests that H5N1 mutations may soon enable human-to-human transmission, raising pandemic concerns. [...]

The method triggers immune responses that inhibit melanoma, triple-negative breast cancer, lung carcinoma, and ovarian cancer. Cancer treatment vaccines have been in development since 2010, when the first was approved for prostate cancer, followed by another in 2015 for melanoma. While many therapeutic (rather than preventive) cancer vaccines have been researched since then, none [...]

Scientists have uncovered a critical piece of the puzzle in autoimmune diseases: a protein that helps release immune response molecules. By studying an ultra-rare condition, researchers identified ArfGAP2 as a key player in immune overactivity. Blocking it in mice prevented severe tissue damage, opening the door to potential treatments for a range of immune-related [...]

Quantum gravity is the missing link between general relativity and quantum mechanics, the yet-to-be-discovered key to a unified theory capable of explaining both the infinitely large and the infinitely small. The solution to this puzzle might lie in the humble neutrino, an elementary particle with no electric charge and almost invisible, as it rarely [...]

A Japanese research team found that the oxidized form of glutathione (GSSG) may protect heart tissue by modifying a key protein, potentially offering a novel therapeutic approach for ischemic heart failure. A new study by researchers in Japan suggests that the mitochondria, often called the powerhouse of the cell, could be a key target [...]

Millions of people in England may be living with Long Covid without even realizing it. A large-scale analysis found that nearly 10% suspect they might have the condition but remain uncertain, often due to lack of diagnosis, stigma, or self-doubt. Many Are Unsure If They Have Long Covid Nearly one in ten people (9.1%) [...]

What if poor sleep was doing more than just making you tired? Researchers have discovered that disrupted sleep in older adults interferes with the brain’s ability to clean out waste, leading to memory problems and increasing the risk of neurological diseases like Alzheimer’s. Poor Sleep and Brain Waste Removal Poor sleep in older adults may [...]

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of the many bumps, bruises and scrapes along the way. Certain factors can cause cells to abandon this characteristic and enter a zombie-like state known as senescence where they persist but no longer [...]