Pterostilbene, a compound found naturally in some foods, affects how skeletal muscles process fats by stabilizing a protein called PPARδ and increasing its signaling activity. Pterostilbene, a natural compound found in blueberries, grapes, and other berries, may help muscle cells clear excess fat by protecting a protein that regulates how they use it. Researchers [...]
Scientists have uncovered two surprising forces that help guide how the human brain forms before birth. Before birth, the human brain is shaped in large part by an unusual class of stem cells known as radial glia. These cells help determine which brain cells are produced, when they appear, and how the cerebral cortex, [...]
The findings offer new insights that could help guide the development of future therapies. A protein called human resistin may help flip on one of the immune system’s most powerful inflammatory switches. Researchers at Johns Hopkins Medicine found that resistin can activate Human resistin is a signaling protein associated with inflammation and immune activity. [...]
The most abundant microbes on your skin may not be the ones doing most of the work. Human skin supports vast communities of bacteria, fungi, and viruses that can influence its protective barrier, immune defenses, and overall health. Yet simply cataloging these organisms cannot reveal which ones are active, how they respond to their [...]
Scientists found compounds in a Brazilian tree that hit SARS-CoV-2 on multiple fronts, revealing a promising new lead in the search for COVID-19 treatments. Researchers have found that galloylquinic acids extracted from the leaves of Copaifera lucens Dwyer, a tree native to Brazil and found mainly in the Atlantic Forest, can act against SARS-CoV-2 [...]
A newly identified link between amino acid metabolism and cholesterol production may help prostate tumors adapt to hormone therapy. Prostate cancer can find ways around treatments designed to deprive tumors of the hormones they need to grow. Weill Cornell Medicine investigators have now traced one possible route of resistance to amino acid metabolism, where [...]
Physicists around the world remain deeply divided on key mysteries of the universe, from dark matter to quantum gravity. The standard cosmological model failed to gain majority support, and no leading theory dominated the survey results. The largest survey ever conducted among physicists worldwide reveals surprisingly little agreement on some of the field’s biggest [...]
New findings raise questions about the role of microbes living in the lungs. More than 35 trillion bacteria live throughout the human body, forming microbiomes in the gut, mouth, lungs, skin, and urogenital tract. Researchers increasingly recognize that these microbial communities are connected to both health and disease, but much about what individual microbes [...]
From the preface of the book Global Health Care Equivalency in the Age of Nanotechnology, Nanomedicine and Artificial Intelligence, Edited by Frank Boehm: Since the publication of my first book (Nanomedical Device and Systems Design: Challenges, Possibilities, Visions – CRC Press, 2013), it became increasingly evident that synergies between the concurrently rapid advances in [...]
Pelacarsen didn’t protect heart health despite lowering levels of a protein particle, “Lp(a),” in a large clinical trial — a result with important implications for cardiovascular drug research. Dive Brief: An RNA drug from Novartis and Ionis Pharmaceuticals failed to reduce the risk of heart attacks, strokes and death in a clinical trial, an outcome [...]
