Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called protein degraders which can be deployed to combat what have previously been regarded as "undruggable" diseases, including cancers and neurodegenerative diseases. Protein degrader molecules are heralding a revolution in drug discovery, with more than 50 drugs [...]
Largest discovery of new virus species sheds light on the hidden virosphere. Artificial intelligence (AI) has been used to reveal details of a diverse and fundamental branch of life living right under our feet and in every corner of the globe. These viruses not only play significant roles in human health but are also prevalent in extreme [...]
Research indicates that COVID-19 survivors face doubled risks of severe cardiac events for years after recovery, especially if hospitalized. People with A, B, or AB blood types are particularly vulnerable, highlighting the need for personalized approaches to heart health post-COVID. COVID-19 and Cardiovascular Risk A history of COVID-19 can double the risk of heart attack, stroke, [...]
For long periods of its history, artificial intelligence has lurked in the hinterland of science, often unloved and unfunded—but two Nobel prizes in one week suggest its time in the sunshine has finally arrived. First on Tuesday, Geoffrey Hinton and John Hopfield won the physics prize for their pioneering work in creating the foundations of modern [...]
A new study provides further evidence that consciousness depends on communication between the brain’s sensory and cognitive regions in the cortex. Our brains are constantly making predictions about our surroundings, enabling us to focus on and respond to unexpected events. A recent study explores how this predictive process functions during consciousness and how it [...]
UC study of Fernald data links environmental phenols to heart toxicities Environmental phenols are present in numerous everyday consumer products, serving as preservatives in packaged foods, parabens in shampoos, and bisphenol A (BPA) in plastic dishware. Consequently, people are consistently exposed to these chemicals on a daily basis. Some of these environmental phenols are [...]
University of Pittsburgh researchers report that deep brain stimulation (DBS) can effectively enhance motor functions in individuals with arm and hand paralysis due to brain injuries, with promising results from early human and monkey trials. Researchers from the University of Pittsburgh School of Medicine have demonstrated that deep brain stimulation can immediately improve arm [...]
Findings supported by the NIH pave the way for the development of genetic testing, clinical trials, and therapies. Researchers at the National Institutes of Health (NIH) and their collaborators have discovered a gene linked to certain inherited retinal diseases (IRDs). These diseases, which impair the eye’s light-sensitive retina and pose a threat to vision, collectively affect [...]
Patients tolerated synthetic THC (dronabinol) well, without the adverse effects commonly associated with existing Alzheimer’s agitation medications. A study conducted by researchers from Johns Hopkins University School of Medicine and Tufts University School of Medicine found that a pill form of dronabinol, an FDA-approved synthetic version of THC (the main ingredient in marijuana), reduces agitation in Alzheimer’s patients by an [...]
Understanding rare diseases Rare diseases affect less than 5 people out of 10,000. However, this still amounts to about 7% of the world’s population, with over 10,000 such conditions. Almost all are genetic in origin, with a few being autoimmune or infectious. Most such patients undergo a diagnostic and therapeutic odyssey involving extensive and [...]
