UC study of Fernald data links environmental phenols to heart toxicities
Environmental phenols are present in numerous everyday consumer products, serving as preservatives in packaged foods, parabens in shampoos, and bisphenol A (BPA) in plastic dishware. Consequently, people are consistently exposed to these chemicals on a daily basis.
Some of these environmental phenols are known to have cardiac toxicities. Now, an interdisciplinary study involving four University of Cincinnati College of Medicine professors is revealing their adverse impact on the heart’s electrical properties, and the research has been published in the journal Environmental Health.
“This is the first study to look at the impact of phenol exposure on cardiac electrical activity in humans,” said Hong-Sheng Wang, PhD, professor in the Department of Pharmacology, Physiology and Neurobiology and the study’s lead author.
Researchers used data from the Fernald Community Cohort, which includes nearly 10,000 people who lived near the former U.S. Department of Energy uranium processing site at Fernald, outside Cincinnati, and participated in the Fernald Medical Monitoring Program between 1990 and 2008.
Much of the cohort did not experience exposure to uranium beyond the radiation received by the general population. Wang and his team used their data, including biological samples and medical records, in the study so uranium exposure would not be a factor in the findings — making them relevant to the general population. Because urine samples and electrocardiograms, or EKGs, were collected on the same day, the results were significant for analyzing exposure to environmental phenols.
The EKGs, which measure cardiac electrical activities, were read by board-certified physicians, and the urine samples were sent to the Centers for Disease Control and Prevention for exposure analysis.
Findings on the Heart’s Electrical Activity
One goal of the study was to identify any changes in EKG parameters associated with environmental phenol exposure.
The heart is driven by electrical activity, so anything affecting its electrical properties can have a detrimental impact and possibly result in arrhythmias.
The research concluded higher exposure to some environmental phenols is associated with altered cardiac electrical activity.
Researchers found higher exposure to BPA, BPF, and BPA+F in women is associated with a longer PR interval, a delay in the time it takes for electrical signals to move from the atria at the top of the heart to the ventricles.
“Our findings were highly sex-specific,” said Wang. In women, researchers identified an association with longer QRS duration, or contraction of the ventricles, and dysfunction of the electrical impulses of the heart.
“It was particularly pronounced in women with higher body mass indexes,” said Wang.
In men, researchers found higher exposure to triclocarban (TCC), an antimicrobial agent, led to longer QT intervals in the heart — meaning the heart’s electrical system is taking too long to recharge, a situation that can contribute to heart rhythm dysfunction. TCC has since been banned in the United States.
Implications for Heart Health
Wang also pointed out that typical exposure levels alone are unlikely to cause clinically significant heart disease in healthy people.
“These were not dramatic changes that we observed, but moderate changes to cardiac electrical activity,” he said. “However, they were particularly pronounced in certain subpopulations.”
He said the altered cardiac activity could exacerbate existing heart disease or arrhythmias in a patient, especially older adults or those with other risk factors.
“Now there are new chemicals out there, so the next step would be to examine these newer environmental chemicals and to focus on their impact on an individual level in those who are predisposed to heart disease,” said Wang.
Reference: “Association of same-day urinary phenol levels and cardiac electrical alterations: analysis of the Fernald Community Cohort” by Jack Rubinstein, Susan M. Pinney, Changchun Xie and Hong-Sheng Wang, 19 September 2024, Environmental Health.
DOI: 10.1186/s12940-024-01114-x
Other contributors in this study included Susan Pinney, PhD, FACE, professor of epidemiology in the Department of Environmental and Public Health Sciences; Jack Rubinstein, MD, FACC, professor of clinical cardiology in the Department of Internal Medicine; and Changchun Xie, PhD, professor in the Department of Biostatistics, Health Informatics and Data Sciences.
This study was funded by grants from the National Institute of Environmental Health and the University of Cincinnati Center for Environmental Genetics.
News
Studies detail high rates of long COVID among healthcare, dental workers
Researchers have estimated approximately 8% of Americas have ever experienced long COVID, or lasting symptoms, following an acute COVID-19 infection. Now two recent international studies suggest that the percentage is much higher among healthcare workers [...]
Melting Arctic Ice May Unleash Ancient Deadly Diseases, Scientists Warn
Melting Arctic ice increases human and animal interactions, raising the risk of infectious disease spread. Researchers urge early intervention and surveillance. Climate change is opening new pathways for the spread of infectious diseases such [...]
Scientists May Have Found a Secret Weapon To Stop Pancreatic Cancer Before It Starts
Researchers at Cold Spring Harbor Laboratory have found that blocking the FGFR2 and EGFR genes can stop early-stage pancreatic cancer from progressing, offering a promising path toward prevention. Pancreatic cancer is expected to become [...]
Breakthrough Drug Restores Vision: Researchers Successfully Reverse Retinal Damage
Blocking the PROX1 protein allowed KAIST researchers to regenerate damaged retinas and restore vision in mice. Vision is one of the most important human senses, yet more than 300 million people around the world are at [...]
Differentiating cancerous and healthy cells through motion analysis
Researchers from Tokyo Metropolitan University have found that the motion of unlabeled cells can be used to tell whether they are cancerous or healthy. They observed malignant fibrosarcoma cells and [...]
This Tiny Cellular Gate Could Be the Key to Curing Cancer – And Regrowing Hair
After more than five decades of mystery, scientists have finally unveiled the detailed structure and function of a long-theorized molecular machine in our mitochondria — the mitochondrial pyruvate carrier. This microscopic gatekeeper controls how [...]
Unlocking Vision’s Secrets: Researchers Reveal 3D Structure of Key Eye Protein
Researchers have uncovered the 3D structure of RBP3, a key protein in vision, revealing how it transports retinoids and fatty acids and how its dysfunction may lead to retinal diseases. Proteins play a critical [...]
5 Key Facts About Nanoplastics and How They Affect the Human Body
Nanoplastics are typically defined as plastic particles smaller than 1000 nanometers. These particles are increasingly being detected in human tissues: they can bypass biological barriers, accumulate in organs, and may influence health in ways [...]
Measles Is Back: Doctors Warn of Dangerous Surge Across the U.S.
Parents are encouraged to contact their pediatrician if their child has been exposed to measles or is showing symptoms. Pediatric infectious disease experts are emphasizing the critical importance of measles vaccination, as the highly [...]
AI at the Speed of Light: How Silicon Photonics Are Reinventing Hardware
A cutting-edge AI acceleration platform powered by light rather than electricity could revolutionize how AI is trained and deployed. Using photonic integrated circuits made from advanced III-V semiconductors, researchers have developed a system that vastly [...]
A Grain of Brain, 523 Million Synapses, Most Complicated Neuroscience Experiment Ever Attempted
A team of over 150 scientists has achieved what once seemed impossible: a complete wiring and activity map of a tiny section of a mammalian brain. This feat, part of the MICrONS Project, rivals [...]
The Secret “Radar” Bacteria Use To Outsmart Their Enemies
A chemical radar allows bacteria to sense and eliminate predators. Investigating how microorganisms communicate deepens our understanding of the complex ecological interactions that shape our environment is an area of key focus for the [...]
Psychologists explore ethical issues associated with human-AI relationships
It's becoming increasingly commonplace for people to develop intimate, long-term relationships with artificial intelligence (AI) technologies. At their extreme, people have "married" their AI companions in non-legally binding ceremonies, and at least two people [...]
When You Lose Weight, Where Does It Actually Go?
Most health professionals lack a clear understanding of how body fat is lost, often subscribing to misconceptions like fat converting to energy or muscle. The truth is, fat is actually broken down into carbon [...]
How Everyday Plastics Quietly Turn Into DNA-Damaging Nanoparticles
The same unique structure that makes plastic so versatile also makes it susceptible to breaking down into harmful micro- and nanoscale particles. The world is saturated with trillions of microscopic and nanoscopic plastic particles, some smaller [...]
AI Outperforms Physicians in Real-World Urgent Care Decisions, Study Finds
The study, conducted at the virtual urgent care clinic Cedars-Sinai Connect in LA, compared recommendations given in about 500 visits of adult patients with relatively common symptoms – respiratory, urinary, eye, vaginal and dental. [...]
