A recent study published in The Lancet never-before-seen unprecedented details on the exceptionally high death rates due to the COVID-19 pandemic both within nations and internationally. Regions including Mexico City, Peru, and Bolivia experienced some of the most significant reductions in life expectancy from 2019 to 2021. This research, offering new estimates from the 2021 Global Burden of Disease Study, delivers the most thorough examination yet of the pandemic’s impact on human health. It reveals that the worldwide average life expectancy decreased by 1.6 years between 2019 and 2021, a sharp reversal from past increases.
Among GBD’s other key findings, child mortality continued to drop amid the COVID-19 pandemic, with half a million fewer deaths among children under 5 in 2021 compared to 2019. Mortality rates among children under 5 decreased by 7% from 2019 to 2021.
“For adults worldwide, the COVID-19 pandemic has had a more profound impact than any event seen in half a century, including conflicts and natural disasters,” says co-first author Dr. Austin E. Schumacher, Acting Assistant Professor of Health Metrics Sciences at the Institute for Health Metrics and Evaluation (IHME) at the University of Washington. “Life expectancy declined in 84% of countries and territories during this pandemic, demonstrating the devastating potential impacts of novel pathogens.”
New Insights on Mortality Rates
Researchers from IHME identified high mortality during the COVID-19 pandemic in places that were previously less recognized and/or reported. For example, the study reveals that after accounting for the age of the population, countries such as Jordan and Nicaragua had high excess mortality due to the COVID-19 pandemic that was not apparent in previous all-age excess mortality estimates. In analyzing subnational locations not previously investigated, the South African provinces of KwaZulu-Natal and Limpopo had among the highest age-adjusted excess mortality rates and largest life expectancy declines during the pandemic in the world. Conversely, the places with some of the lowest age-adjusted excess mortality from the pandemic during this period included Barbados, New Zealand, and Antigua and Barbuda.
During the COVID-19 pandemic, mortality among older people worldwide rose in ways unseen in the previous 70 years. While the pandemic was devastating, killing approximately 16 million people around the globe in 2020 and 2021 combined, it did not completely erase historic progress – life expectancy at birth rose by nearly 23 years between 1950 and 2021.
GBD 2021 analyzes past and current demographic trends at global, regional, national, and subnational levels. The study provides globally comparable measures of excess mortality and is one of the first studies to fully evaluate demographic trends in the context of the first two years of the COVID-19 pandemic. In estimating excess deaths due to the pandemic, the authors accounted for deaths from the virus that causes COVID-19, SARS-CoV-2, as well as deaths associated with indirect effects of the pandemic, such as delays in seeking health care.
Excess Mortality and Life Expectancy Estimates
Employing innovative methods to measure mortality, excess mortality from the COVID-19 pandemic, life expectancy, and population, the study authors estimate that the pandemic caused global mortality to jump among people over age 15, rising by 22% for males and 17% for females from 2019 to 2021.
GBD 2021 goes beyond assessing the impact of the first two years of the COVID-19 pandemic. As the authors note, it also offers “implications for the future of health-care systems, economies, and societies and … a valuable foundation for policy evaluation, development, and implementation around the world.”
GBD 2021 indicates that, despite early warnings that COVID-19 could threaten the gains that the world had made in saving children’s lives, these improvements continued during the pandemic, albeit at a slower pace. Still, stark differences in child mortality persist between regions. In 2021, one out of every four children who died worldwide lived in South Asia, while two out of every four children who died lived in sub-Saharan Africa.
“Our study suggests that, even after taking stock of the terrible loss of lives the world experienced due to the pandemic, we have made incredible progress over 72 years since 1950, with child mortality continuing to drop globally,” said co-first author Dr. Hmwe Hmwe Kyu, Associate Professor of Health Metrics Sciences at IHME at the University of Washington. “Now, continuing to build on our successes, while preparing for the next pandemic and addressing the vast disparities in health across countries, should be our greatest focuses.”
Population Trends and Future Challenges
The GBD 2021 study also assessed population trends. Beginning in 2017, the rate of global population growth began to drop following years of stagnation. Then, during the COVID-19 pandemic, these declines accelerated. As of 2021, 56 countries have reached peak population. Now, these countries are seeing their populations shrink. However, rapid population growth has continued in many lower-income countries. In addition, populations around the world are aging. Between 2000 and 2021, the number of people who were 65 and older grew faster than the number of people under age 15 in 188 countries and territories.
“Slowing population growth and aging populations, along with the concentration of future population growth shifting to poorer locations with worse health outcomes, will bring about unprecedented social, economic, and political challenges, such as labor shortages in areas where younger populations are shrinking and resource scarcity in places where population size continues to expand rapidly,” says Dr. Schumacher. “This is worth restating, as these issues will require significant policy forethought to address in the affected regions. As one example, nations around the world will need to cooperate on voluntary emigration, for which one source of useful guidance is the UN’s Global Compact for Safe, Orderly and Regular Migration.”
Reference: “Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021” by GBD 2021 Demographics Collaborators, 11 March 2024, The Lancet.
DOI: 10.1016/S0140-6736(24)00476-8

News
Baffling Scientists for Centuries: New Study Unravels Mystery of Static Electricity
ISTA physicists demonstrate that contact electrification depends on the contact history of materials. For centuries, static electricity has intrigued and perplexed scientists. Now, researchers from the Waitukaitis group at the Institute of Science and [...]
Tumor “Stickiness” – Scientists Develop Potential New Way To Predict Cancer’s Spread
UC San Diego researchers have developed a device that predicts breast cancer aggressiveness by measuring tumor cell adhesion. Weakly adherent cells indicate a higher risk of metastasis, especially in early-stage DCIS. This innovation could [...]
Scientists Just Watched Atoms Move for the First Time Using AI
Scientists have developed a groundbreaking AI-driven technique that reveals the hidden movements of nanoparticles, essential in materials science, pharmaceuticals, and electronics. By integrating artificial intelligence with electron microscopy, researchers can now visualize atomic-level changes that were [...]
Scientists Sound Alarm: “Safe” Antibiotic Has Led to an Almost Untreatable Superbug
A recent study reveals that an antibiotic used for liver disease patients may increase their risk of contracting a dangerous superbug. An international team of researchers has discovered that rifaximin, a commonly prescribed antibiotic [...]
Scientists Discover Natural Compound That Stops Cancer Progression
A discovery led by OHSU was made possible by years of study conducted by University of Portland undergraduates. Scientists have discovered a natural compound that can halt a key process involved in the progression [...]
Scientists Just Discovered an RNA That Repairs DNA Damage – And It’s a Game-Changer
Our DNA is constantly under threat — from cell division errors to external factors like sunlight and smoking. Fortunately, cells have intricate repair mechanisms to counteract this damage. Scientists have uncovered a surprising role played by [...]
What Scientists Just Discovered About COVID-19’s Hidden Death Toll
COVID-19 didn’t just claim lives directly—it reshaped mortality patterns worldwide. A major international study found that life expectancy plummeted across most of the 24 analyzed countries, with additional deaths from cardiovascular disease, substance abuse, and mental [...]
Self-Propelled Nanoparticles Improve Immunotherapy for Non-Invasive Bladder Cancer
A study led by Pohang University of Science and Technology (POSTECH) and the Institute for Bioengineering of Catalonia (IBEC) in South Korea details the creation of urea-powered nanomotors that enhance immunotherapy for bladder cancer. The nanomotors [...]
Scientists Develop New System That Produces Drinking Water From Thin Air
UT Austin researchers have developed a biodegradable, biomass-based hydrogel that efficiently extracts drinkable water from the air, offering a scalable, sustainable solution for water access in off-grid communities, emergency relief, and agriculture. Discarded food [...]
AI Unveils Hidden Nanoparticles – A Breakthrough in Early Disease Detection
Deep Nanometry (DNM) is an innovative technique combining high-speed optical detection with AI-driven noise reduction, allowing researchers to find rare nanoparticles like extracellular vesicles (EVs). Since EVs play a role in disease detection, DNM [...]
Inhalable nanoparticles could help treat chronic lung disease
Nanoparticles designed to release antibiotics deep inside the lungs reduced inflammation and improved lung function in mice with symptoms of chronic obstructive pulmonary disease By Grace Wade Delivering medication to the lungs with inhalable nanoparticles [...]
New MRI Study Uncovers Hidden Lung Abnormalities in Children With Long COVID
Long COVID is more than just lingering symptoms—it may have a hidden biological basis that standard medical tests fail to detect. A groundbreaking study using advanced MRI technology has uncovered significant lung abnormalities in [...]
AI Struggles with Abstract Thought: Study Reveals GPT-4’s Limits
While GPT-4 performs well in structured reasoning tasks, a new study shows that its ability to adapt to variations is weak—suggesting AI still lacks true abstract understanding and flexibility in decision-making. Artificial Intelligence (AI), [...]
Turning Off Nerve Signals: Scientists Develop Promising New Pancreatic Cancer Treatment
Pancreatic cancer reprograms nerve cells to fuel its growth, but blocking these connections can shrink tumors and boost treatment effectiveness. Pancreatic cancer is closely linked to the nervous system, according to researchers from the [...]
New human antibody shows promise for Ebola virus treatment
New research led by scientists at La Jolla Institute for Immunology (LJI) reveals the workings of a human antibody called mAb 3A6, which may prove to be an important component for Ebola virus therapeutics. [...]
Early Alzheimer’s Detection Test – Years Before Symptoms Appear
A new biomarker test can detect early-stage tau protein clumping up to a decade before it appears on brain scans, improving early Alzheimer’s diagnosis. Unlike amyloid-beta, tau neurofibrillary tangles are directly linked to cognitive decline. Years [...]