For a third season, COVID-19 cases are rising ahead of the holidays, this time with a more recent variant driving infections.
Cases of JN. 1 infections rose from just more than 8% at the end of November to double digits by Dec. 9, according to CDC data.
International health experts say the sudden jump isn’t cause for concern—yet.
Here’s what you need to know:
What is JN.1?
The JN.1 variant is closely related to another omicron subvariant named BA.2.86, according to the CDC.
Health officials started tracking BA.2.86 in August but noticed some cases had a single change to the spike protein, the part of a virus that penetrates host cells to cause infection, according to the CDC.
JN.1 was first detected as its own variant in the United States in September, the CDC reported, and has since been identified in 11 countries.
The variant made up just 0.1% of cases at the end of October, according to CDC data, but that number has now increased exponentially.
“The continued growth of JN.1 suggests that it is either more transmissible or better at evading our immune systems,” the CDC said at the beginning of December.
This means the change to the spike protein may make it easier for the virus to get into cells than previous variants or make it harder for human immune systems to identify the virus as COVID-19.
International health experts also noted the trend, with JN.1 officially classified as its own variant by the World Health Organization on Dec. 19.
“Based on the available evidence, the additional global public health risk posed by JN.1 is currently evaluated as low,” the WHO said in a post on X, formerly known as Twitter. “Despite this, with the onset of winter in the Northern Hemisphere, JN.1 could increase the burden of respiratory infections in many countries.”
Does the updated COVID booster protect against JN.1?
The CDC says the JN.1 variant is closely related enough to previous variants that the updated COVID-19 booster shot will provide protection.
“The spike protein—called a ‘spike’ because it looks like tiny spikes on the virus’ surface—plays a crucial role in helping the virus infect people. Because of this, the spike protein is also the part of the virus that vaccines target, meaning vaccines should work against JN.1 and BA.2.86 similarly,” the CDC said.
The agency continued by saying it expects “treatments and testing to remain effective” against JN.1, in line with previous variants.
The most recent COVID-19 booster was approved by the Food and Drug Administration and then recommended by the CDC in September, but a large number of Americans have opted out of the shot.
Do I need the new COVID booster?
The vaccine is recommended for everyone over the age of six months, regardless of previous vaccine status, the CDC says.
Despite this, fewer and fewer Americans are adding the shot to their regular seasonal vaccines, like the flu shot.
By the middle of November, only 36 million adults and 3.5 million children had received the latest shot, equivalent to about 14% of the American public, ABC News reported.
That’s compared to the nearly 70% of Americans who completed the primary series of COVID-19 vaccines, McClatchy News reported.
Cases of JN.1 have seen some of the highest increases in Midwestern states, CDC data shows, correlating with a pocket of the U.S. that has been particularly hesitant to get the new shot.
Ahead of the holidays, the CDC reiterated the vaccine, masking and keeping your distance when you might be sick are still the most effective ways to prevent a COVID-19 infection and prevent its spread.
The agency said this also extends to other respiratory illnesses making the rounds this season.
“Many viruses spread more during the holiday season, so it is important to get all recommended vaccines, including flu, COVID-19 and RSV, as soon as possible,” the CDC said. “This will give you the best protection against these respiratory diseases, including while traveling and gathering with family and friends. These vaccines will also make your illness less severe if you do get sick.”

News
Baffling Scientists for Centuries: New Study Unravels Mystery of Static Electricity
ISTA physicists demonstrate that contact electrification depends on the contact history of materials. For centuries, static electricity has intrigued and perplexed scientists. Now, researchers from the Waitukaitis group at the Institute of Science and [...]
Tumor “Stickiness” – Scientists Develop Potential New Way To Predict Cancer’s Spread
UC San Diego researchers have developed a device that predicts breast cancer aggressiveness by measuring tumor cell adhesion. Weakly adherent cells indicate a higher risk of metastasis, especially in early-stage DCIS. This innovation could [...]
Scientists Just Watched Atoms Move for the First Time Using AI
Scientists have developed a groundbreaking AI-driven technique that reveals the hidden movements of nanoparticles, essential in materials science, pharmaceuticals, and electronics. By integrating artificial intelligence with electron microscopy, researchers can now visualize atomic-level changes that were [...]
Scientists Sound Alarm: “Safe” Antibiotic Has Led to an Almost Untreatable Superbug
A recent study reveals that an antibiotic used for liver disease patients may increase their risk of contracting a dangerous superbug. An international team of researchers has discovered that rifaximin, a commonly prescribed antibiotic [...]
Scientists Discover Natural Compound That Stops Cancer Progression
A discovery led by OHSU was made possible by years of study conducted by University of Portland undergraduates. Scientists have discovered a natural compound that can halt a key process involved in the progression [...]
Scientists Just Discovered an RNA That Repairs DNA Damage – And It’s a Game-Changer
Our DNA is constantly under threat — from cell division errors to external factors like sunlight and smoking. Fortunately, cells have intricate repair mechanisms to counteract this damage. Scientists have uncovered a surprising role played by [...]
What Scientists Just Discovered About COVID-19’s Hidden Death Toll
COVID-19 didn’t just claim lives directly—it reshaped mortality patterns worldwide. A major international study found that life expectancy plummeted across most of the 24 analyzed countries, with additional deaths from cardiovascular disease, substance abuse, and mental [...]
Self-Propelled Nanoparticles Improve Immunotherapy for Non-Invasive Bladder Cancer
A study led by Pohang University of Science and Technology (POSTECH) and the Institute for Bioengineering of Catalonia (IBEC) in South Korea details the creation of urea-powered nanomotors that enhance immunotherapy for bladder cancer. The nanomotors [...]
Scientists Develop New System That Produces Drinking Water From Thin Air
UT Austin researchers have developed a biodegradable, biomass-based hydrogel that efficiently extracts drinkable water from the air, offering a scalable, sustainable solution for water access in off-grid communities, emergency relief, and agriculture. Discarded food [...]
AI Unveils Hidden Nanoparticles – A Breakthrough in Early Disease Detection
Deep Nanometry (DNM) is an innovative technique combining high-speed optical detection with AI-driven noise reduction, allowing researchers to find rare nanoparticles like extracellular vesicles (EVs). Since EVs play a role in disease detection, DNM [...]
Inhalable nanoparticles could help treat chronic lung disease
Nanoparticles designed to release antibiotics deep inside the lungs reduced inflammation and improved lung function in mice with symptoms of chronic obstructive pulmonary disease By Grace Wade Delivering medication to the lungs with inhalable nanoparticles [...]
New MRI Study Uncovers Hidden Lung Abnormalities in Children With Long COVID
Long COVID is more than just lingering symptoms—it may have a hidden biological basis that standard medical tests fail to detect. A groundbreaking study using advanced MRI technology has uncovered significant lung abnormalities in [...]
AI Struggles with Abstract Thought: Study Reveals GPT-4’s Limits
While GPT-4 performs well in structured reasoning tasks, a new study shows that its ability to adapt to variations is weak—suggesting AI still lacks true abstract understanding and flexibility in decision-making. Artificial Intelligence (AI), [...]
Turning Off Nerve Signals: Scientists Develop Promising New Pancreatic Cancer Treatment
Pancreatic cancer reprograms nerve cells to fuel its growth, but blocking these connections can shrink tumors and boost treatment effectiveness. Pancreatic cancer is closely linked to the nervous system, according to researchers from the [...]
New human antibody shows promise for Ebola virus treatment
New research led by scientists at La Jolla Institute for Immunology (LJI) reveals the workings of a human antibody called mAb 3A6, which may prove to be an important component for Ebola virus therapeutics. [...]
Early Alzheimer’s Detection Test – Years Before Symptoms Appear
A new biomarker test can detect early-stage tau protein clumping up to a decade before it appears on brain scans, improving early Alzheimer’s diagnosis. Unlike amyloid-beta, tau neurofibrillary tangles are directly linked to cognitive decline. Years [...]