It’s been more than five decades since Dustin Hoffman’s character in “The Graduate” was offered a kernel of wisdom about the path to prosperity.
“Plastics,” he’s told by Mr. McGuire, the starched corporate executive who offers the advice. “There’s a great future in plastics.”
Plastics have indeed been a game changer for humanity, and the enormous range of cheap, durable plastic goods, from food containers and PVC pipes to polyester clothing and single-use medical products, have inarguably improved life.
The problem, as nearly everyone knows, is that plastics are forever and very little of it has been recycled. The U.N. has estimated that most of the 400 million metric tons churned out annually — a doubling of production since 2000 — will remain on Earth in some form as they are broken down into teeny specks by sunlight, wind and the sea.
Roughly 20 years ago, Richard Thompson, a marine biologist, first discovered a worrisome accumulation of small plastic particles in ocean habitats and coined the word “microplastics.” Since then, scientists have been finding these fragments everywhere, from remote mountain peaks and the Arctic to the ocean seafloor.
In the decade that followed, scientists began to discover microplastics embedded in a wide range of living creatures, including in the seafood we eat. More recently, microplastics have been found inside the human body: in our lungs, our blood, our feces and in breast milk.
In 2021, Italian researchers for the first time identified microplastics in human placenta.
The question, scientists have been asking with increasing urgency, is whether these synthetic, foreign bodies pose a threat to human health.
“We know microplastics are everywhere, we know they are harmful to marine life and to our fisheries, but the research side of how they impact humans is still catching up,” said Imari Walker-Franklin, an environmental engineer and chemistry researcher at RTI International who studies microplastics.
“Plastic People,” a new documentary directed by Ben Addelman and Ziya Tong, surveys the emerging science on microplastics and arrives at a troubling conclusion: The potential health risks associated with plastic pollution are becoming hard to ignore.
The film, which debuts Saturday at the SXSW Film Festival in Austin, Texas, follows the work of microplastic researchers in a half-dozen countries, including a pair of Turkish scientists who said they recently discovered microplastics inside the human brain. Some of the particles were found deep inside the tissue of cancerous brain tumors.
“The revelation that the human body is full of microplastics is a recent one and I think the implications will become one of the most dominant health and environmental stories of our time,” said Rick Smith, president of the Canadian Climate Institute and one of the film’s executive producers. “It doesn’t matter if you’re rich or poor, there’s no sheltering yourself from this kind of new pollution.”
Microplastics, fragments less than five millimeters in size that can usually be seen by the naked eye, are not to be confused with nanoplastics, which are smaller than a speck of dust and are often the inadvertent byproduct of plastic production. Research on the potential health effects of nanoplastics is still in its infancy, at least compared with the studies on microplastics, a field that has been rapidly expanding over the past few years.
Scientific evidence of the effects of microplastics on humans is limited, at least in peer-reviewed literature. A study in the journal Environmental Science & Technology in 2022 found that patients with inflammatory bowel disease had a significantly higher amount of microplastics in their feces than those without the disease. A small University of Hawaii study published last November cataloged the growing presence of microplastics in the placentas of new mothers.
And a paper published on Thursday in the New England Journal of Medicine reported that people who had microplastics in their cardiovascular systems were at heightened risk for complications from heart attacks and strokes.
The researchers found that microplastics had become embedded in the fatty plaque that clings to the walls of blood vessels, and that patients with plastic-infused plaque were 4.5 times as likely to experience a heart attack, stroke or death compared with those whose plaque was free of microplastics. The study included 312 people who had undergone surgery to remove plaque from the carotid artery in the neck. Researchers followed them for nearly three years.
Dr. Giuseppe Paolisso, an author of the study, said it appeared that microplastics, along with nanoplastics, made those fatty blobs of plaque more frail, increasing the risk that they could dislodge from the artery wall, block the flow of blood in a smaller vessel and prompt a heart attack or stroke.
“This is the first evidence that microplastic pollution in the blood is related to a disease,” said Dr. Paolisso, a professor of internal medicine at the University of Campania Luigi Vanvitelli in Caserta, Italy. More research is needed to confirm the findings, he added.
There are a number of theories about how microplastics affect the body. They include the potential for inflammation caused by a foreign body that lodges in human tissue and the toxic compounds that make up many plastics, many of which are known to harm human health.
Nienke Vrisekoop, a microplastics researcher at the University Medical Center Utrecht in the Netherlands, said she found that immune cells that come in contact with microplastics die three times as quickly than those that do not. She said that the polystyrene commonly used to produce packing materials was especially toxic to the immune cells that consumed them.
Research conducted by another Dutch researcher, Barbro Melgert, found that microplastics inhibited the development of lung structures grown in her lab. Professor Melgert, a respiratory immunologist at the University of Groningen, said nylon seemed to be most damaging to the lung structures. Polyvinyl chloride, or PVC, she discovered, was the least toxic of the plastics she tested.
Professor Melgert is still trying to understand how microplastics affect living cells, but she suspects that the damage may be related to any number of chemicals that can leach from plastics into the human body.
Although she knows the results of the study do not definitively prove harm to humans, nor do they quantify the risks, previous research on nylon factory workers showed extensive lung damage among those exposed to large amounts of nylon particles.
Foreign particulate matter like asbestos, coal dust or cigarette smoke often proves problematic to human health, she noted. “If the particulate is organic and digestible, at least your body can break it down eventually and get rid of it,” Professor Melgert said. “Plastic is different. It can just stay in the lung.”
Image

Credit…Sedat Gündoğdu
The same can most likely be said for microplastics that find their way into the brain. The discovery, arguably the new film’s most significant revelation, was made by two Turkish researchers, Sedat Gündoğdu, a biologist, and Emrah Çeltikçi, a neurosurgeon.
Dr. Gündoğdu, a researcher at Cukurova University, has been studying microplastic pollution since 2016. Over the years, he has collaborated on scores of peer-reviewed studies documenting microplastics in fisheries, soil, table salt and intravenous fluid bags, and his alarm has grown with each new discovery.
It was only a matter of time, he said, before researchers would discover microplastics in the human brain. “It’s scary but not surprising,” he said.
Despite the sense of urgency and doom conveyed by “Plastic People,” Ms. Tong, the co-director and a former host of the Discovery Channel science show “Daily Planet,” hopes the film can inspire change, the way “Silent Spring,” the 1962 book that documented the dangers of agricultural pesticides and helped lead to a ban on DDT, did.
On an individual level, that means encouraging consumers to reduce their reliance on single-use plastics, which make up 40 percent of global plastics production, she said.
But that also means persuading political leaders to take regulatory action. At the moment, Ms. Tong has her eye on a U.N. gathering next month in Ottawa, where delegates from 175 countries will resume negotiations on a treaty proposal that would curb the explosive growth of plastic pollution. The talks have been snagged by industry opposition at times.
“It’s not like we need some remarkable new invention to address the problem,” Ms. Tong said. “We just have to use less plastic.”

News
Studies detail high rates of long COVID among healthcare, dental workers
Researchers have estimated approximately 8% of Americas have ever experienced long COVID, or lasting symptoms, following an acute COVID-19 infection. Now two recent international studies suggest that the percentage is much higher among healthcare workers [...]
Melting Arctic Ice May Unleash Ancient Deadly Diseases, Scientists Warn
Melting Arctic ice increases human and animal interactions, raising the risk of infectious disease spread. Researchers urge early intervention and surveillance. Climate change is opening new pathways for the spread of infectious diseases such [...]
Scientists May Have Found a Secret Weapon To Stop Pancreatic Cancer Before It Starts
Researchers at Cold Spring Harbor Laboratory have found that blocking the FGFR2 and EGFR genes can stop early-stage pancreatic cancer from progressing, offering a promising path toward prevention. Pancreatic cancer is expected to become [...]
Breakthrough Drug Restores Vision: Researchers Successfully Reverse Retinal Damage
Blocking the PROX1 protein allowed KAIST researchers to regenerate damaged retinas and restore vision in mice. Vision is one of the most important human senses, yet more than 300 million people around the world are at [...]
Differentiating cancerous and healthy cells through motion analysis
Researchers from Tokyo Metropolitan University have found that the motion of unlabeled cells can be used to tell whether they are cancerous or healthy. They observed malignant fibrosarcoma cells and [...]
This Tiny Cellular Gate Could Be the Key to Curing Cancer – And Regrowing Hair
After more than five decades of mystery, scientists have finally unveiled the detailed structure and function of a long-theorized molecular machine in our mitochondria — the mitochondrial pyruvate carrier. This microscopic gatekeeper controls how [...]
Unlocking Vision’s Secrets: Researchers Reveal 3D Structure of Key Eye Protein
Researchers have uncovered the 3D structure of RBP3, a key protein in vision, revealing how it transports retinoids and fatty acids and how its dysfunction may lead to retinal diseases. Proteins play a critical [...]
5 Key Facts About Nanoplastics and How They Affect the Human Body
Nanoplastics are typically defined as plastic particles smaller than 1000 nanometers. These particles are increasingly being detected in human tissues: they can bypass biological barriers, accumulate in organs, and may influence health in ways [...]
Measles Is Back: Doctors Warn of Dangerous Surge Across the U.S.
Parents are encouraged to contact their pediatrician if their child has been exposed to measles or is showing symptoms. Pediatric infectious disease experts are emphasizing the critical importance of measles vaccination, as the highly [...]
AI at the Speed of Light: How Silicon Photonics Are Reinventing Hardware
A cutting-edge AI acceleration platform powered by light rather than electricity could revolutionize how AI is trained and deployed. Using photonic integrated circuits made from advanced III-V semiconductors, researchers have developed a system that vastly [...]
A Grain of Brain, 523 Million Synapses, Most Complicated Neuroscience Experiment Ever Attempted
A team of over 150 scientists has achieved what once seemed impossible: a complete wiring and activity map of a tiny section of a mammalian brain. This feat, part of the MICrONS Project, rivals [...]
The Secret “Radar” Bacteria Use To Outsmart Their Enemies
A chemical radar allows bacteria to sense and eliminate predators. Investigating how microorganisms communicate deepens our understanding of the complex ecological interactions that shape our environment is an area of key focus for the [...]
Psychologists explore ethical issues associated with human-AI relationships
It's becoming increasingly commonplace for people to develop intimate, long-term relationships with artificial intelligence (AI) technologies. At their extreme, people have "married" their AI companions in non-legally binding ceremonies, and at least two people [...]
When You Lose Weight, Where Does It Actually Go?
Most health professionals lack a clear understanding of how body fat is lost, often subscribing to misconceptions like fat converting to energy or muscle. The truth is, fat is actually broken down into carbon [...]
How Everyday Plastics Quietly Turn Into DNA-Damaging Nanoparticles
The same unique structure that makes plastic so versatile also makes it susceptible to breaking down into harmful micro- and nanoscale particles. The world is saturated with trillions of microscopic and nanoscopic plastic particles, some smaller [...]
AI Outperforms Physicians in Real-World Urgent Care Decisions, Study Finds
The study, conducted at the virtual urgent care clinic Cedars-Sinai Connect in LA, compared recommendations given in about 500 visits of adult patients with relatively common symptoms – respiratory, urinary, eye, vaginal and dental. [...]