Conventional microscopes produce enlarged images of small structures or objects with the help of light. Nanoparticles, however, are so small that they hardly absorb or scatter light and, hence, remain invisible. Optical resonators increase the interaction between light and nanoparticles: They capture light in smallest space by reflecting it thousands of times between two mirrors. In case a nanoparticle is located in the captured light field, it interacts thousands of times with the light such that the change in light intensity can be measured. “The light field has various intensities at different points in space. This allows conclusions to be drawn with respect to the position of the nanoparticle in the three-dimensional space,” says Dr. Larissa Kohler from KIT’s Physikalisches Institut.
Resonator makes movements of nanoparticles visible
And not only that: “If a nanoparticle is located in water, it collides with water molecules that move in arbitrary directions due to thermal energy. These collisions cause the nanoparticle to move randomly. This Brownian motion can now also be detected,” the experts adds. “So far, it has been impossible for an optical resonator to trackthe motion of a nanoparticle in space. It was only possible to state whether or not the particle is located in the light field,” Kohler explains. In the novel fiber-based Fabry-Pérot resonator, highly reflecting mirrors are located on the ends of glass fibers. It allows us to derive the hydrodynamic radius of the particle, that is the thickness of the water surrounding the particle, from its three-dimensional movement. This is important, because this thickness changes the properties of the nanoparticle. “As a result of the hydrate shell, it is possible to detect nanoparticles that would have been too small without it,” Kohler says. Moreover, the hydrate shell around proteins or other biological nanoparticles might have an impact on biological processes.
A potential application of the resonator may be the detection of three-dimensional motion with high temporal resolution and characterization of optical properties of biological nanoparticles, such as proteins, DNA origami, or viruses. In this way, the sensor might provide insights into not yet understood biological processes.
News
According to Researchers, Your Breathing Patterns Could Hold the Key to Better Memory
Breathing synchronizes brain waves that support memory consolidation. A new study from Northwestern Medicine reports that, much like a conductor harmonizes various instruments in an orchestra to create a symphony, breathing synchronizes hippocampal brain waves to [...]
The Hidden Culprit Behind Alzheimer’s Revealed: Microglia Under the Microscope
Researchers at the CUNY Graduate Center have made a groundbreaking discovery in Alzheimer’s disease research, identifying a critical link between cellular stress in the brain and disease progression. Their study focuses on microglia, the brain’s immune [...]
“Mirror Bacteria” Warning: A New Kind of Life Could Pose a Global Threat
Mirror life, a concept involving synthetic organisms with reversed molecular structures, carries significant risks despite its potential for medical advancements. Experts warn that mirror bacteria could escape natural biological controls, potentially evolving to exploit [...]
Lingering Viral Fragments: The Hidden Cause of Long COVID
Long COVID, affecting 5-10% of COVID-19 patients, might be caused by the enduring presence of the virus in the body. Research suggests that viral fragments, possibly live, linger and lead to symptoms. Addressing this involves antiviral treatments, enhanced [...]
Hidden Scars: How COVID Lockdowns Altered Teen Brains Forever
Research from the University of Washington revealed that COVID-19 lockdowns led to accelerated cortical thinning in adolescents, impacting brain development significantly. This effect was more pronounced in females than males, raising concerns about long-term brain health. The study [...]
Simple Blood Test To Detect Dementia Before Symptoms Appear
UCLA researchers have identified placental growth factor (PlGF) as a potential blood biomarker for early detection of cognitive impairment and dementia. High PlGF levels correlate with increased vascular permeability, suggesting its role in the development [...]
Investing Goldman Sachs asks ‘Is curing patients a sustainable business model?’
Goldman Sachs analysts attempted to address a touchy subject for biotech companies, especially those involved in the pioneering “gene therapy” treatment: cures could be bad for business in the long run. “Is curing patients [...]
The risks of reversed chirality: Study highlights dangers of mirror organisms
A groundbreaking study evaluates the feasibility, risks, and ethical considerations of creating mirror bacteria with reversed chirality, highlighting potential threats to health and ecosystems. In a recent study published in Science, a team of researchers [...]
Alarming Mutation in H5N1 Virus Raises Pandemic Red Flags
NIH-funded study concludes that the risk of human infection remains low A recent study published in Science and funded by the National Institutes of Health (NIH) has found that a single alteration in a protein on the surface [...]
Scientists Discover Genetic Changes Linked to Autism, Schizophrenia
The Tbx1 gene influences brain volume and social behavior in autism and schizophrenia, with its deficiency linked to amygdala shrinkage and impaired social incentive evaluation. A study published in Molecular Psychiatry has linked changes in brain [...]
How much permafrost will melt this century, and where will its carbon go?
Among the many things global warming will be melting this century—sea ice, land glaciers and tourist businesses in seaside towns across the world—is permafrost. Lying underneath 15% of the northern hemisphere, permafrost consists of [...]
A Physics Discovery So Strange It’s Changing Quantum Theory
MIT physicists surprised to discover electrons in pentalayer graphene can exhibit fractional charge. New theoretical research from MIT physicists explains how it could work, suggesting that electron interactions in confined two-dimensional spaces lead to novel quantum states, [...]
Inside the Nano-Universe: New 3D X-Ray Imaging Transforms Material Science
A cutting-edge X-ray method reveals the 3D orientation of nanoscale material structures, offering fresh insights into their functionality. Researchers at the Swiss Light Source (SLS) have developed a groundbreaking technique called X-ray linear dichroic orientation tomography [...]
X-chromosome study reveals hidden genetic links to Alzheimer’s disease
Despite decades of research, the X-chromosome’s impact on Alzheimer’s was largely ignored until now. Explore how seven newly discovered genetic loci could revolutionize our understanding of the disease. Conventional investigations of the genetic contributors [...]
The Unresolved Puzzle of Long COVID: 30% of Young People Still Suffer After Two Years
A UCL study found that 70% of young people with long Covid recovered within 24 months, but recovery was less likely among older teenagers, females, and those from deprived backgrounds. Researchers emphasized the need [...]
Needle-Free: New Nano-Vaccine Effective Against All COVID-19 Variants
A new nano-vaccine developed by TAU and the University of Lisbon offers a needle-free, room-temperature-storable solution against COVID-19, targeting all key variants effectively. Professor Ronit Satchi-Fainaro’s lab at Tel Aviv University’s Faculty of Medical and [...]
