Modern Approaches to Augmentation of Brain Function
This book covers recent advances in neural technology that provide for enhancements for brain function. It addresses a broad range of neural phenomena occurring in the brain circuits involved in perception, cognition, emotion and action, that represent the building blocks of behavior and cognition. Augmentation of brain function can be achieved by using brain implants for recordings, stimulation, or drug delivery. Alternative methods include employing brain-machine interfaces, as well as noninvasive activation of certain brain areas. This volume evaluates existing methods of brain augmentation while discussing the brain circuitry and neuronal mechanisms that make augmentation possible.
This volume offers novel insights into brain disorders, and explores new devices for brain repair while also addressing the philosophical and ethical implications of brain augmentation. The information in this book is relevant to researchers in the fields of neuroscience, engineering, and clinical practice.
Advance Praise for Modern Approaches to Augmentation of Brain Function:
“This impressive book by leading experts in neuroscience and neuroengineering lays out the future of brain augmentation, in which the human mind and machine merge, leading to a rapid exponential growth of the power of humanity.”
Ray Kurzweil, best-selling author, inventor, entrepreneur and a recipient of the National Medal of Technology and Innovation (1999), and the Lemelson-MIT Prize (2001)
“This book employs a holistic approach in covering the recent advances in the fields of neuroscience, neuroinformatics, neurotechnology and neuro-psycho-pharmacology. Each chapter of the book covers major aspects of modern brain research in connection with the human mind and behavior, and is authored by researchers with unique expertise in their field. ”
Ioan Dumitrache, Prof. Dr. Eng. Faculty of Computer Science, Polytechnic University of Bucharest, Bucharest, Romania
“This book presents compelling perspectives on what interactive neuroscience will look like in the future, delving into the innovatory ideas of a diverse set of neuroscientists, and speculating on the different ways computer chips implanted in the brains of humans can effect intelligence and communication.”
György Buzsáki, MD, PhD is the Biggs Professor of Neuroscience, NYU School of Medicine, New York, NY
Immune Aspects of Biopharmaceuticals and Nanomedicines
1st Edition
Raj Bawa, Janos Szebeni, Thomas J Webster, Gerald F. Audette
The enormous advances in the immunology of biotherapeutics and nanomedicines in the past two decades have necessitated an authoritative and comprehensive reference that can be relied upon by immunologists, biomedical researchers, physicians, pharmaceutical and formulation scientists, clinicians, regulatory personnel, technology transfer officers, venture capitalists, and policy makers alike.
Table of Contents
Proteins as Medicines: The Era of Biologics
Raj Bawa, János Szebeni, Thomas J. Webster, and Gerald F. Audette
Immunological Issues with Medicines of Nano Size: The Price of Dimension Paradox
János Szebeni and Raj Bawa
Immunotherapy and Vaccines
Johanna Poecheim and Gerrit Borchard
Emerging Trends in Delivery of Novel Vaccine Formulations
Trinh Phuong Vo, Rikhav P. Gala, Thripthy Chandran, Sucheta D’Sa, and Ruhi V. Ubale
Current Understanding of Interactions between Nanoparticles and the Immune System
Marina A. Dobrovolskaia, Michael Shurin, and Anna A. Shvedova
Auto-antibodies as Biomarkers for Disease Diagnosis
Angelika Lueking, Heike Göhler, and Peter Schulz-Knappe
The Accelerated Blood Clearance Phenomenon of PEGylated Nanocarriers
Amr S. Abu Lila and Tatsuhiro Ishida
Anti-PEG Immunity Against PEGylated Therapeutics
Amr S. Abu Lila and Tatsuhiro Ishida
Complement Activation: Challenges to Nanomedicine Development
Dennis E. Hourcade, Christine T. N. Pham, and Gregory M. Lanza
Intravenous Immunoglobulin at the Borderline of Nanomedicines and Biologicals: Antithrombogenic Effect via Complement Attenuation
Milan Basta
Lessons Learned from the Porcine CARPA Model: Constant and Variable Responses to Different Nanomedicines and Administration Protocols
Rudolf Urbanics, Péter Bedőcs, and János Szebeni
Blood Cell Changes in Complement Activation-Related Pseudoallergy: Intertwining of Cellular and Humoral Interactions
Zsófia Patkó and János Szebeni
Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities
Kaushik Thanki, Emily Falkenberg, Monique Gangloff, and Camilla Foged
Lipid Nanoparticles Technology Induced Immunomodulatory Effects of siRNA
Ranjita Shegokar and Prabhat Mishra
Nanovaccines against Intracellular Pathogens Using Coxiella burnetii as a Model Organism
Erin J. van Schaik, Anthony E. Gregory, Gerald F. Audette, and James E. Samuel
Immunogenicity Assessment for Therapeutic Protein Products
FDA
Assay Development and Validation for Immunogenicity Testing of Therapeutic Protein Products: Guidance for Industry
FDA
The “Sentinel”: A Nanomedical Strategy for Radical Immune System Enhancement
Frank Boehm and Angelika Domschke
Immunotherapy for Gliomas and Other Intracranial Malignancies
Mario Ganau, Gianfranco K. I. Ligarotti, Salvatore Chibbaro, and Andrea Soddu
Liposome-Induced Complement Activation-Related Pseudoallergy
Amr S. Abu Lila, Janos Szebeni, and Tatsuhiro Ishida
The Physics of the Mind and Brain Disorders
Frank Boehm (NanoApps Medical CEO) and Angelika Domschke contributed the chapter : “Application of a Conceptual Nanomedical Platform to Facilitate the Mapping of the Human Brain: Survey of Cognitive Functions and Implications”.
The book covers recent advances in the understanding of brain structure, function and disorders based on the fundamental principles of physics. It covers a broad range of physical phenomena occurring in the brain circuits for perception, cognition, emotion and action, representing the building blocks of the mind.
It provides novel insights into the devastating brain disorders of the mind such as schizophrenia, dementia, autism, aging or addictions, as well as into the new devices for brain repair.
The book is aimed at basic researchers in the fields of neuroscience, physics, biophysics and clinicians in the fields of neurology, neurosurgery, psychology, psychiatry.
The Physics of the Mind and Brain Disorders is available in both hardcover and ebook from Springer Press.
Neurophotonics and Brain Mapping
Frank Boehm contributed to Neurophotonics and Brain Mapping, edited by Yu Chen and Babek Kateb.
The book was released by CRC Press on April 6 2017.
About the Book
Understanding how the brain works and developing effective therapeutics are important in advancing neuroscience and improving clinical patient care. This book covers state-of-the-art research and development in optical technologies and applications for brain mapping and therapeutics. It provides a comprehensive overview of various methods developed using light, both microscopic and macroscopic techniques. Recent developments in minimally-invasive endoscopic imaging of deep brain structure and function, as well as light-based therapy are also reviewed.
Frank Boehm contributed to “Brief History of Brain Mapping and Neurophotonics: From Technological Discoveries to Brain Initiatives” by Babak Kateb, Vicky Yamamoto, Frank Boehm, Alexandra Jalali, Vassiliy Tsytsarev, Bahram Jalali, Derek Backer,Brian Pikul, Parham Yashar, and Yu Chen. He also contributed to the chapter “UV-Based Imaging Technologies for Intraoperative Brain Mapping” by Babak Kateb, Frank Boehm, Ray Chu, Samuel R. Cheng, Keith Black, and Shouleh Nikzad.
Chapters contributed to the following books:
1) Chapter 15: “Potential Strategies for Advanced Nanomedical Device Ingress and Egress, Natation, Mobility, and Navigation”,
Frank J. Boehm
in
Mark J. Schulz, Vesselin N. Shanov, YeoHeung Yun, eds., Nanomedicine Materials, Devices, and Systems, Artech House, (Norwood MA, USA)
http://www.amazon.com/Nanomedicine-Particles-Implants-Engineering-Medicine/dp/1596932791
(published August 1, 2009)
2) “The Vascular Cartographic Scanning Nanodevice”
Frank J. Boehm
in
Handbook of Clinical Nanomedicine, Two-Volume Set
Raj Bawa, Gerald F. Audette, Israel Rubinstein
Pan Stanford
https://www.crcpress.com/Handbook-of-Clinical-Nanomedicine-Two-Volume-Set/Bawa-Audette-Rubinstein/p/book/9789814316170
(published May 12, 2016)
3) “UV-Based Imaging Technologies for Intraoperative Brain Mapping”
Babak Kateb, Frank Boehm, Ray Chu, Shouleh Nikzad
in
Neurophotonics and Brain Mapping
Yu Chen, Babak Kateb
https://www.crcpress.com/Neurophotonics-and-Brain-Mapping/Chen-Kateb/p/book/9781482236859
(forthcoming April 6, 2017)
4) “Application of a Conceptual Nanomedical Platform to Facilitate the Mapping of the Human Brain: Survey of Cognitive Functions and Implications”
A. Domschke and F.J. Boehm
in
The Physics of the Mind and Brain Disorders
Integrated Neural Circuits Supporting the Emergence of Mind
Editors: Dr. Ioan Opris, Manuel F. Casanova
http://www.springer.com/us/book/9783319296722
(forthcoming Jul 11, 2017)
5) “The “Sentinel”: A Conceptual Nanomedical Strategy for the Enhancement of the Human Immune System”
A. Domschke and F.J. Boehm
in
Handbook of Clinical Nanomedicine – Volume 3
Raj Bawa, Gerald F. Audette, Israel Rubinstein
(forthcoming tbd)
Journal Publications
“Superseding the Hourglass Effect Toward the Successful Commercialization of Nanotechnology in the Medical Sciences – We Require a Change in Perspective”
Krishnan Chakravarthy, Frank Boehm, and Wendy Sanhai-Madar
Cureus. 2016 Jul; 8(7): e670. Published online 2016 Jul 5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977221/
“Nanotechnology: Promising New Paradigm for the Control of Pain”
Krishnan Chakravarthy MD, PhD, Frank Boehm, and Paul Christo MD, MBA
(in progress, journal publication – tbd)
“Facilitating a Hypothetical (Neocortical) Brain/Cloud Interface (B/CI) – Conceptual Nanomedical Strategies”
Martins NRB, Angelica A, Chakravarthy K, Svidinenko Y, Boehm FJ, Opris I, Lebedev M, Swan M, Rosenfeld JV, Hogg T, Freitas Jr RA
(in progress, journal publication – tbd)
“Facilitating a Hypothetical (Neocortical) Brain/Cloud Interface (B/CI) – Ethical, Moral, Sociological, and Philosophical Considerations”
Martins NRB, Angelica A, Chakravarthy K, Svidinenko Y, Boehm FJ, Opris I, Lebedev M, Swan M, Rosenfeld JV, Hogg T, Freitas Jr RA
(in progress, journal publication – tbd)
Citations
“Determination of hemodynamic risk for vascular disease in planar artery bifurcations”
Otero-Cacho A, Aymerich M, Flores-Arias MT, Abal M, Álvarez E, Pérez-Muñuzuri V, Muñuzuri AP.
Scientific Reports, 12 February 2018(8), 2795
www.nature.com
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Prioritizing older individuals for COVID-19 boosters yields best public health outcomes
In a recent study published in PLoS Computational Biology, researchers used mathematical modelling to evaluate whether prioritizing older individuals for coronavirus disease 2019 (COVID-19) booster vaccinations consistently leads to optimal public [...]
AI accurately diagnoses genetic condition from facial photographs
A Yale School of Medicine team reports in a new study that an artificial intelligence (AI) model was able to reliably diagnose people living with Marfan syndrome from a [...]
New study links brain cell structures to memory loss in aging and dementia
In a recent study published in Science Advances, a group of researchers assessed whether dendritic spine head diameter in the temporal cortex is a better predictor of episodic memory performance [...]
A common parasite could deliver drugs to the brain— turning Toxoplasma gondii from foe into friend
Parasites take an enormous toll on human and veterinary health. But researchers may have found a way for patients with brain disorders and a common brain parasite to become frenemies. A [...]
New research shows how testosterone may shield against severe Covid-19
A new study has revealed important information about how a patient's testosterone level can help protect them from severe Covid-19. Previous research involving Swansea University investigated how sex hormones [...]
Lensless fluorescence detection system provides highly sensitive water quality assessment
Researchers have shown that a fluorescence detection system that doesn't contain any lenses can provide highly sensitive detection of deadly microorganisms in drinking water. With further development, the new [...]
Cracking the Code of Life: New AI Model Learns DNA’s Hidden Language
DNA is crucial for life, and its organization has been a significant scientific challenge. GROVER, a model developed by BIOTEC, decodes DNA like text, promising advancements in genomics and personalized [...]
Hospital discharges linked to higher MRSA risk for family members
Family members of patients recently discharged from the hospital may have a higher risk of getting an antibiotic-resistant infection, often called a superbug, even if the patient was not [...]
The Paradox of Cognition: Why Thinking Too Hard Can Make You Miserable
New research shows that mental exertion is often linked with negative emotions. A meta-analysis of 170 studies revealed that regardless of the task or population, increased mental effort correlates [...]
Mucosal COVID-19 vaccine prevents airborne transmission of SARS-CoV-2
In a recent study published in Science Advances, researchers evaluated the impact of mucosal versus intramuscular vaccine immunization on airborne infection and transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [...]
Decades-Old Mystery Solved: Scientists Crack the Code of DNA Repair
Researchers from the LMS and LMB have discovered how the D2-I protein complex identifies and repairs DNA damage, a breakthrough that promises to enhance cancer treatments by improving our understanding of [...]
New Study Reveals Disturbing Rise in Cancer Among Gen X and Millennials
Recent findings from an American Cancer Society study show rising cancer rates among younger generations, with increases in incidence and mortality across multiple cancer types. This generational shift in [...]
CEPI and WHO call for urgent global research to prepare for the next pandemic
The Coalition for Epidemic Preparedness Innovations (CEPI) and the World Health Organization (WHO) today called on researchers and governments to strengthen and accelerate global research to prepare for the [...]
What is AI? Everyone thinks they know but no one can agree.
Internet nastiness, name-calling, and other not-so-petty, world-altering disagreements.. AI is sexy, AI is cool. AI is entrenching inequality, upending the job market, and wrecking education. AI is a theme-park [...]
Is Consciousness Continuous? A New Study Challenges Old Notions
Researchers have long studied how consciousness forms in the brain. Professor Ekrem Dere proposes defining conscious phases via behavioral observations and learning curves, using sudden insights to identify conscious [...]
Neural Vulnerabilities and Resilience in Alzheimer’s Explored
Summary: Researchers uncover how specific brain cells and circuits become vulnerable in Alzheimer’s disease and identify factors that may promote resilience to cognitive decline. Analyzing gene expression in over 1.3 [...]
Scientists Expose Long-Term Cognitive Impacts of Mild COVID-19
Research indicates that while the most severe effects of SARS-CoV-2 were observed in patients with acute COVID-19, individuals who experienced milder cases and were not hospitalized also reported symptoms of memory loss [...]
New nanoparticles boost immune system in mice to fight melanoma and breast cancer
Vanderbilt researchers have developed a set of nanoparticles that stimulate the immune system in mice to fight cancer and may eventually do the same in humans. The research, led [...]
Breakthrough in Antimicrobial Technology with Cinnamon-Based Nanokiller
The need for innovative antimicrobial agents has become increasingly urgent due to the rise of antibiotic-resistant pathogens and the persistent threat of infections acquired during hospital stays. Traditional antibiotics [...]
The Silent Battle Within: How Your Organs Choose Between Mom and Dad’s Genes
Research reveals that selective expression of maternal or paternal X chromosomes varies by organ, driven by cellular competition. A new study published today (July 26) in Nature Genetics by the Lymphoid [...]
Study identifies genes increasing risk of severe COVID-19
Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers from the University Hospital Bonn (UKB) and [...]
Small regions of the brain can take micro-naps while the rest of the brain is awake and vice versa
Sleep and wake: They're totally distinct states of being that define the boundaries of our daily lives. For years, scientists have measured the difference between these instinctual brain processes [...]
Redefining Consciousness: Small Regions of the Brain Can Take Micro-Naps While the Rest of the Brain Is Awake
The study broadly reveals how fast brain waves, previously overlooked, establish fundamental patterns of sleep and wakefulness. Scientists have developed a new method to analyze sleep and wake states [...]
AI Reveals Health Secrets Through Facial Temperature Mapping
Researchers have found that different facial temperatures correlate with chronic illnesses like diabetes and high blood pressure, and these can be detected using AI with thermal cameras. They highlight [...]
Breakthrough in aging research: Blocking IL-11 extends lifespan and improves health in mice
In a recent study published in the journal Nature, a team of researchers used murine models and various pharmacological and genetic approaches to examine whether pro-inflammatory signaling involving interleukin (IL)-11, [...]
Promise for a universal influenza vaccine: Scientists validate theory using 1918 flu virus
New research led by Oregon Health & Science University reveals a promising approach to developing a universal influenza vaccine—a so-called "one and done" vaccine that confers lifetime immunity against [...]
