Modern Approaches to Augmentation of Brain Function
This book covers recent advances in neural technology that provide for enhancements for brain function. It addresses a broad range of neural phenomena occurring in the brain circuits involved in perception, cognition, emotion and action, that represent the building blocks of behavior and cognition. Augmentation of brain function can be achieved by using brain implants for recordings, stimulation, or drug delivery. Alternative methods include employing brain-machine interfaces, as well as noninvasive activation of certain brain areas. This volume evaluates existing methods of brain augmentation while discussing the brain circuitry and neuronal mechanisms that make augmentation possible.
This volume offers novel insights into brain disorders, and explores new devices for brain repair while also addressing the philosophical and ethical implications of brain augmentation. The information in this book is relevant to researchers in the fields of neuroscience, engineering, and clinical practice.
Advance Praise for Modern Approaches to Augmentation of Brain Function:
“This impressive book by leading experts in neuroscience and neuroengineering lays out the future of brain augmentation, in which the human mind and machine merge, leading to a rapid exponential growth of the power of humanity.”
Ray Kurzweil, best-selling author, inventor, entrepreneur and a recipient of the National Medal of Technology and Innovation (1999), and the Lemelson-MIT Prize (2001)
“This book employs a holistic approach in covering the recent advances in the fields of neuroscience, neuroinformatics, neurotechnology and neuro-psycho-pharmacology. Each chapter of the book covers major aspects of modern brain research in connection with the human mind and behavior, and is authored by researchers with unique expertise in their field. ”
Ioan Dumitrache, Prof. Dr. Eng. Faculty of Computer Science, Polytechnic University of Bucharest, Bucharest, Romania
“This book presents compelling perspectives on what interactive neuroscience will look like in the future, delving into the innovatory ideas of a diverse set of neuroscientists, and speculating on the different ways computer chips implanted in the brains of humans can effect intelligence and communication.”
György Buzsáki, MD, PhD is the Biggs Professor of Neuroscience, NYU School of Medicine, New York, NY
Immune Aspects of Biopharmaceuticals and Nanomedicines
1st Edition
Raj Bawa, Janos Szebeni, Thomas J Webster, Gerald F. Audette
The enormous advances in the immunology of biotherapeutics and nanomedicines in the past two decades have necessitated an authoritative and comprehensive reference that can be relied upon by immunologists, biomedical researchers, physicians, pharmaceutical and formulation scientists, clinicians, regulatory personnel, technology transfer officers, venture capitalists, and policy makers alike.
Table of Contents
Proteins as Medicines: The Era of Biologics
Raj Bawa, János Szebeni, Thomas J. Webster, and Gerald F. Audette
Immunological Issues with Medicines of Nano Size: The Price of Dimension Paradox
János Szebeni and Raj Bawa
Immunotherapy and Vaccines
Johanna Poecheim and Gerrit Borchard
Emerging Trends in Delivery of Novel Vaccine Formulations
Trinh Phuong Vo, Rikhav P. Gala, Thripthy Chandran, Sucheta D’Sa, and Ruhi V. Ubale
Current Understanding of Interactions between Nanoparticles and the Immune System
Marina A. Dobrovolskaia, Michael Shurin, and Anna A. Shvedova
Auto-antibodies as Biomarkers for Disease Diagnosis
Angelika Lueking, Heike Göhler, and Peter Schulz-Knappe
The Accelerated Blood Clearance Phenomenon of PEGylated Nanocarriers
Amr S. Abu Lila and Tatsuhiro Ishida
Anti-PEG Immunity Against PEGylated Therapeutics
Amr S. Abu Lila and Tatsuhiro Ishida
Complement Activation: Challenges to Nanomedicine Development
Dennis E. Hourcade, Christine T. N. Pham, and Gregory M. Lanza
Intravenous Immunoglobulin at the Borderline of Nanomedicines and Biologicals: Antithrombogenic Effect via Complement Attenuation
Milan Basta
Lessons Learned from the Porcine CARPA Model: Constant and Variable Responses to Different Nanomedicines and Administration Protocols
Rudolf Urbanics, Péter Bedőcs, and János Szebeni
Blood Cell Changes in Complement Activation-Related Pseudoallergy: Intertwining of Cellular and Humoral Interactions
Zsófia Patkó and János Szebeni
Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities
Kaushik Thanki, Emily Falkenberg, Monique Gangloff, and Camilla Foged
Lipid Nanoparticles Technology Induced Immunomodulatory Effects of siRNA
Ranjita Shegokar and Prabhat Mishra
Nanovaccines against Intracellular Pathogens Using Coxiella burnetii as a Model Organism
Erin J. van Schaik, Anthony E. Gregory, Gerald F. Audette, and James E. Samuel
Immunogenicity Assessment for Therapeutic Protein Products
FDA
Assay Development and Validation for Immunogenicity Testing of Therapeutic Protein Products: Guidance for Industry
FDA
The “Sentinel”: A Nanomedical Strategy for Radical Immune System Enhancement
Frank Boehm and Angelika Domschke
Immunotherapy for Gliomas and Other Intracranial Malignancies
Mario Ganau, Gianfranco K. I. Ligarotti, Salvatore Chibbaro, and Andrea Soddu
Liposome-Induced Complement Activation-Related Pseudoallergy
Amr S. Abu Lila, Janos Szebeni, and Tatsuhiro Ishida
The Physics of the Mind and Brain Disorders
Frank Boehm (NanoApps Medical CEO) and Angelika Domschke contributed the chapter : “Application of a Conceptual Nanomedical Platform to Facilitate the Mapping of the Human Brain: Survey of Cognitive Functions and Implications”.
The book covers recent advances in the understanding of brain structure, function and disorders based on the fundamental principles of physics. It covers a broad range of physical phenomena occurring in the brain circuits for perception, cognition, emotion and action, representing the building blocks of the mind.
It provides novel insights into the devastating brain disorders of the mind such as schizophrenia, dementia, autism, aging or addictions, as well as into the new devices for brain repair.
The book is aimed at basic researchers in the fields of neuroscience, physics, biophysics and clinicians in the fields of neurology, neurosurgery, psychology, psychiatry.
The Physics of the Mind and Brain Disorders is available in both hardcover and ebook from Springer Press.
Neurophotonics and Brain Mapping
Frank Boehm contributed to Neurophotonics and Brain Mapping, edited by Yu Chen and Babek Kateb.
The book was released by CRC Press on April 6 2017.
About the Book
Understanding how the brain works and developing effective therapeutics are important in advancing neuroscience and improving clinical patient care. This book covers state-of-the-art research and development in optical technologies and applications for brain mapping and therapeutics. It provides a comprehensive overview of various methods developed using light, both microscopic and macroscopic techniques. Recent developments in minimally-invasive endoscopic imaging of deep brain structure and function, as well as light-based therapy are also reviewed.
Frank Boehm contributed to “Brief History of Brain Mapping and Neurophotonics: From Technological Discoveries to Brain Initiatives” by Babak Kateb, Vicky Yamamoto, Frank Boehm, Alexandra Jalali, Vassiliy Tsytsarev, Bahram Jalali, Derek Backer,Brian Pikul, Parham Yashar, and Yu Chen. He also contributed to the chapter “UV-Based Imaging Technologies for Intraoperative Brain Mapping” by Babak Kateb, Frank Boehm, Ray Chu, Samuel R. Cheng, Keith Black, and Shouleh Nikzad.
Chapters contributed to the following books:
1) Chapter 15: “Potential Strategies for Advanced Nanomedical Device Ingress and Egress, Natation, Mobility, and Navigation”,
Frank J. Boehm
in
Mark J. Schulz, Vesselin N. Shanov, YeoHeung Yun, eds., Nanomedicine Materials, Devices, and Systems, Artech House, (Norwood MA, USA)
http://www.amazon.com/Nanomedicine-Particles-Implants-Engineering-Medicine/dp/1596932791
(published August 1, 2009)
2) “The Vascular Cartographic Scanning Nanodevice”
Frank J. Boehm
in
Handbook of Clinical Nanomedicine, Two-Volume Set
Raj Bawa, Gerald F. Audette, Israel Rubinstein
Pan Stanford
https://www.crcpress.com/Handbook-of-Clinical-Nanomedicine-Two-Volume-Set/Bawa-Audette-Rubinstein/p/book/9789814316170
(published May 12, 2016)
3) “UV-Based Imaging Technologies for Intraoperative Brain Mapping”
Babak Kateb, Frank Boehm, Ray Chu, Shouleh Nikzad
in
Neurophotonics and Brain Mapping
Yu Chen, Babak Kateb
https://www.crcpress.com/Neurophotonics-and-Brain-Mapping/Chen-Kateb/p/book/9781482236859
(forthcoming April 6, 2017)
4) “Application of a Conceptual Nanomedical Platform to Facilitate the Mapping of the Human Brain: Survey of Cognitive Functions and Implications”
A. Domschke and F.J. Boehm
in
The Physics of the Mind and Brain Disorders
Integrated Neural Circuits Supporting the Emergence of Mind
Editors: Dr. Ioan Opris, Manuel F. Casanova
http://www.springer.com/us/book/9783319296722
(forthcoming Jul 11, 2017)
5) “The “Sentinel”: A Conceptual Nanomedical Strategy for the Enhancement of the Human Immune System”
A. Domschke and F.J. Boehm
in
Handbook of Clinical Nanomedicine – Volume 3
Raj Bawa, Gerald F. Audette, Israel Rubinstein
(forthcoming tbd)
Journal Publications
“Superseding the Hourglass Effect Toward the Successful Commercialization of Nanotechnology in the Medical Sciences – We Require a Change in Perspective”
Krishnan Chakravarthy, Frank Boehm, and Wendy Sanhai-Madar
Cureus. 2016 Jul; 8(7): e670. Published online 2016 Jul 5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977221/
“Nanotechnology: Promising New Paradigm for the Control of Pain”
Krishnan Chakravarthy MD, PhD, Frank Boehm, and Paul Christo MD, MBA
(in progress, journal publication – tbd)
“Facilitating a Hypothetical (Neocortical) Brain/Cloud Interface (B/CI) – Conceptual Nanomedical Strategies”
Martins NRB, Angelica A, Chakravarthy K, Svidinenko Y, Boehm FJ, Opris I, Lebedev M, Swan M, Rosenfeld JV, Hogg T, Freitas Jr RA
(in progress, journal publication – tbd)
“Facilitating a Hypothetical (Neocortical) Brain/Cloud Interface (B/CI) – Ethical, Moral, Sociological, and Philosophical Considerations”
Martins NRB, Angelica A, Chakravarthy K, Svidinenko Y, Boehm FJ, Opris I, Lebedev M, Swan M, Rosenfeld JV, Hogg T, Freitas Jr RA
(in progress, journal publication – tbd)
Citations
“Determination of hemodynamic risk for vascular disease in planar artery bifurcations”
Otero-Cacho A, Aymerich M, Flores-Arias MT, Abal M, Álvarez E, Pérez-Muñuzuri V, Muñuzuri AP.
Scientific Reports, 12 February 2018(8), 2795
www.nature.com
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A new nano-vaccine developed by TAU and the University of Lisbon offers a needle-free, room-temperature-storable solution against COVID-19, targeting all key variants effectively. Professor Ronit Satchi-Fainaro’s lab at Tel Aviv [...]
Photoacoustic PDA-ICG Nanoprobe for Detecting Senescent Cells in Cancer
A study in Scientific Reports evaluated a photoacoustic polydopamine-indocyanine green (PDA-ICG) nanoprobe for detecting senescent cells. Senescent cells play a role in tumor progression and therapeutic resistance, with potential adverse effects [...]
How Dysregulated Cell Signaling Causes Disease
Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, improper [...]
Scientists Develop Super-Strong, Eco-Friendly Plastic That Bacteria Can Eat
Researchers at the Weizmann Institute have developed a biodegradable composite material that could play a significant role in addressing the global plastic waste crisis. Billions of tons of plastic [...]
Building a “Google Maps” for Biology: Human Cell Atlas Revolutionizes Medicine
New research from the Human Cell Atlas offers insights into cell development, disease mechanisms, and genetic influences, enhancing our understanding of human biology and health. The Human Cell Atlas [...]
Bioeconomic Potential: Scientists Just Found 140 Reasons to Love Spider Venom
Researchers at the LOEWE Centre for Translational Biodiversity Genomics (TBG) have discovered a significant diversity of enzymes in spider venom, previously overshadowed by the focus on neurotoxins. These enzymes, [...]
Quantum Algorithms and the Future of Precision Medicine
Precision medicine is reshaping healthcare by tailoring treatments to individual patients based on their unique genetic, environmental, and lifestyle factors. At the forefront of this revolution, the integration of [...]
Scientists Have Discovered a Simple Supplement That Causes Prostate Cancer Cells To Self-Destruct
Menadione, a vitamin K precursor, shows promise in slowing prostate cancer in mice by disrupting cancer cell survival processes, with potential applications for human treatment and myotubular myopathy therapy. [...]
Scientists reveal structural link for initiation of protein synthesis in bacteria
Within a cell, DNA carries the genetic code for building proteins. To build proteins, the cell makes a copy of DNA, called mRNA. Then, another molecule called a ribosome [...]
Vaping Isn’t Safe: Scientists Uncover Alarming Vascular Risks
Smoking and vaping impair vascular function, even without nicotine, with the most significant effects seen in nicotine-containing e-cigarettes. Researchers recommend avoiding both for better health. Researchers have discovered immediate [...]
Twice-Yearly Lenacapavir for PrEP Reduces HIV Infections by 96%
Twice-yearly injections of the capsid inhibitor drug lenacapavir can prevent the vast majority of HIV infections, according to a Phase 3 clinical trial published Wednesday in the New England [...]
Did Social Distancing Begin 6,000 Years Ago? Neolithic Villagers May Have Invented It
Social distancing may have roots 6,000 years ago, as research shows Neolithic villages like Nebelivka used clustered layouts to control disease spread. The phrase “social distancing” became widely recognized [...]
Decoding Alzheimer’s: The Arctic Mutation’s Role in Unusual Brain Structures
Researchers have uncovered how certain genetic mutations lead to unique spherical amyloid plaques in inherited forms of Alzheimer’s, offering insights that could advance our understanding of the disease and improve [...]
How Your “Lizard Brain” Fuels Overthinking and Social Anxiety
New research by Northwestern Medicine reveals how humans have evolved advanced brain regions to interpret others’ thoughts, connecting these areas with the amygdala, a part of the brain involved [...]
How Did Life Begin? Researchers Discover Game-Changing Clue
New research offers a potential explanation for the formation of early Earth protocells. Few questions have captivated humankind more than the mystery of life’s origins on Earth. How did [...]
Printable organic X-ray sensors may transform treatment for cancer patients
An international research team, led by the University of Wollongong (UOW), has found wearable organic X-ray sensors could offer safer radiotherapy protocols for cancer patients. More than 400 people [...]
Unlocking AI’s Potential: MIT’s New Algorithm Boosts Efficiency by 50x
MIT researchers have introduced an efficient reinforcement learning algorithm that enhances AI’s decision-making in complex scenarios, such as city traffic control. By strategically selecting optimal tasks for training, the algorithm [...]
Are Smaller Brains the Future? How AI Could Reshape Human Evolution
AI and Human Evolution As artificial intelligence (AI) becomes increasingly widespread and advanced, it prompts new questions about its impact on human life and society. A recent paper in The Quarterly Review [...]
Antibiotic activity altered by interaction with nanoplastics, new research shows
In a recent study published in Scientific Reports, researchers reported that drug adsorption on micro- and nano-plastics (MNPs) has severe consequences. Introduction Plastic degradation results in the formation of particles [...]
World First: Stem Cell Transplant Restores Vision in Multiple People
A radical stem cell transplant has significantly improved the blurry vision of three people with severe damage to their cornea. The clinical trial, which took place in Japan, is the first of [...]
Clinical Trial: Mushroom Supplement May Halt Prostate Cancer Growth
The bidirectional research examines both laboratory findings and human clinical trial data, revealing that the medicinal use of white button mushrooms reduces the type of cells that suppress the [...]
Scientists propose drug-free method to combat antibiotic-resistant bacteria
Recent estimates indicate that deadly antibiotic-resistant infections will rapidly escalate over the next quarter century. More than 1 million people died from drug-resistant infections each year from 1990 to [...]
New study shows how salmonella tricks gut defenses to cause infection
A new UC Davis Health study has uncovered how Salmonella bacteria, a major cause of food poisoning, can invade the gut even when protective bacteria are present. The research, published in [...]
Chlamydia vaccine shows early promise in mice
An experimental vaccine has shown promise in protecting against the sexually transmitted disease chlamydia, researchers report. Lab mice given the vaccine were able to rapidly clear subsequent chlamydia infections, [...]
Contradictory Discovery: Our Innate Immune System May Fuel Cancer Development
MSK researchers discovered that the innate immune system’s chronic activation due to issues in the Mre11 complex can lead to cancer, highlighting new therapeutic targets. In addition to defending [...]
New study links circadian gene variants to winter depression
Findings suggest that PER3 gene variants prevent adrenal adaptation to winter daylight, leading to serotonin disruption and depression-like behaviors. A recent study in Nature Metabolism used humanized mice with modified PERIOD3 [...]
Quantum Leap for MRI: Atomic Sensors Unlock New Imaging Potential
New atomic sensor technology enhances MRI quality control by tracking hyperpolarized molecules in real-time, with potential benefits for various scientific fields. Magnetic resonance imaging (MRI) is a fundamental tool [...]
MethylGPT unlocks DNA secrets for age and disease prediction
By harnessing advanced AI, MethylGPT decodes DNA methylation with unprecedented accuracy, offering new paths for age prediction, disease diagnosis, and personalized health interventions. In a recent study posted to [...]
“Astonishing” – Scientists Unveil First Blueprint of the Most Complex Molecular Machine in Human Biology
Researchers unveil the inner mechanisms of the most intricate and complex molecular machine in human biology. Scientists at the Centre for Genomic Regulation (CRG) in Barcelona have developed the [...]
