In an article published today in Frontiers in Science, the team outlines how biological computers could surpass today’s electronic computers for certain applications while using a small fraction of the electricity required by today’s computers and server farms.
They’re starting by making small clusters of 50,000 brain cells grown from stem cells and known as organoids. That’s about a third the size of a fruit fly brain. They’re aiming for 10 million neurons which would be about the number of neurons in a tortoise brain. By comparison, the average human brain has more than 80 billion neurons.
The article highlights how the human brain continues to massively outperform machines for particular tasks. Humans, for example, can learn to distinguish two types of objects (such as a dog and a cat) using just a few samples, while AI algorithms need many thousands. And while AI beat the world champion in Go in 2016, it was trained on data from 160,000 games – the equivalent of playing for five hours each day, for more than 175 years.
Brains are also more energy efficient. Our brains are thought to be able to store the equivalent of more than a million times the capacity of an average home computer (2.5 petabytes), using the equivalent of just a few watts of power. US data farms, by contrast, use more than 15,000 megawatts a year, much of it generated by dozens of coal-fired power stations.
In the paper, the authors outline their plan for “organoid intelligence”, or OI, with the brain organoids grown in cell-culture. Although brain organoids aren’t “mini brains”, they share key aspects of brain function and structure. Organoids would need to be dramatically expanded from around 50,000 cells currently.
“For OI, we would need to increase this number to 10 million,” says senior author Prof Thomas Hartung of Johns Hopkins University in Baltimore.
Brett and his colleagues at Cortical Labs have already demonstrated that biocomputers based on human brain cells are possible. A recent paper in Neuron showed that a flat culture of brain cells could learn to play the video game Pong.
“We have shown we can interact with living biological neurons in such a way that compels them to modify their activity, leading to something that resembles intelligence,” says Kagan of the relatively simple Pong-playing DishBrain.
“Working with the team of amazing people assembled by Professor Hartung and colleagues for this Organoid Intelligence collaboration, Cortical Labs is now trying to replicate that work with brain organoids.”
“I would say that replicating [Cortical Labs’] experiment with organoids already fulfils the basic definition of OI,” says Thomas.
“From here on, it’s just a matter of building the community, the tools, and the technologies to realise OI’s full potential,” he said.
“This new field of biocomputing promises unprecedented advances in computing speed, processing power, data efficiency, and storage capabilities – all with lower energy needs,” Brett says. “The particularly exciting aspect of this collaboration is the open and collaborative spirit in which it was formed. Bringing these different experts together is not only vital to optimise for success but provides a critical touch point for industry collaboration.”
And the technology could also enable scientists to better study personalised brain organoids developed from skin or small blood samples of patients suffering from neural disorders, such as Alzheimer’s disease, and run tests to investigate how genetic factors, medicines, and toxins influence these conditions.
TH and LS consult AxoSim. JS is named as inventor on a patent by the University of Luxembourg on the production of midbrain organoids, which is licensed to OrganoTherapeutics SARL, Esch-sur-Alzette, Luxembourg. JS is also co-founder and shareholder of OrganoTherapeutics SARL.
AM is a co-founder and has equity interest in TISMOO, a company dedicated to genetic analysis and human brain organogenesis, focusing on therapeutic applications customized for autism spectrum disorders and other neurological disorders with genetic origins.
The terms of this arrangement have been reviewed and approved by the University of California, San Diego, in accordance with its conflict of interest policies. BK is an inventor on patents for technology related to this paper along with being employed at and holding shares in Cortical Labs Pty Ltd, Melbourne, Australia.
No specific funding or other incentives were provided for involvement in this publication.
News
Scientists Melt Cancer’s Hidden “Power Hubs” and Stop Tumor Growth
Researchers discovered that in a rare kidney cancer, RNA builds droplet-like hubs that act as growth control centers inside tumor cells. By engineering a molecular switch to dissolve these hubs, they were able to halt cancer [...]
Platelet-inspired nanoparticles could improve treatment of inflammatory diseases
Scientists have developed platelet-inspired nanoparticles that deliver anti-inflammatory drugs directly to brain-computer interface implants, doubling their effectiveness. Scientists have found a way to improve the performance of brain-computer interface (BCI) electrodes by delivering anti-inflammatory drugs directly [...]
After 150 years, a new chapter in cancer therapy is finally beginning
For decades, researchers have been looking for ways to destroy cancer cells in a targeted manner without further weakening the body. But for many patients whose immune system is severely impaired by chemotherapy or radiation, [...]
Older chemical libraries show promise for fighting resistant strains of COVID-19 virus
SARS‑CoV‑2, the virus that causes COVID-19, continues to mutate, with some newer strains becoming less responsive to current antiviral treatments like Paxlovid. Now, University of California San Diego scientists and an international team of [...]
Lower doses of immunotherapy for skin cancer give better results, study suggests
According to a new study, lower doses of approved immunotherapy for malignant melanoma can give better results against tumors, while reducing side effects. This is reported by researchers at Karolinska Institutet in the Journal of the National [...]
Researchers highlight five pathways through which microplastics can harm the brain
Microplastics could be fueling neurodegenerative diseases like Alzheimer's and Parkinson's, with a new study highlighting five ways microplastics can trigger inflammation and damage in the brain. More than 57 million people live with dementia, [...]
Tiny Metal Nanodots Obliterate Cancer Cells While Largely Sparing Healthy Tissue
Scientists have developed tiny metal-oxide particles that push cancer cells past their stress limits while sparing healthy tissue. An international team led by RMIT University has developed tiny particles called nanodots, crafted from a metallic compound, [...]
Gold Nanoclusters Could Supercharge Quantum Computers
Researchers found that gold “super atoms” can behave like the atoms in top-tier quantum systems—only far easier to scale. These tiny clusters can be customized at the molecular level, offering a powerful, tunable foundation [...]
A single shot of HPV vaccine may be enough to fight cervical cancer, study finds
WASHINGTON -- A single HPV vaccination appears just as effective as two doses at preventing the viral infection that causes cervical cancer, researchers reported Wednesday. HPV, or human papillomavirus, is very common and spread [...]
New technique overcomes technological barrier in 3D brain imaging
Scientists at the Swiss Light Source SLS have succeeded in mapping a piece of brain tissue in 3D at unprecedented resolution using X-rays, non-destructively. The breakthrough overcomes a long-standing technological barrier that had limited [...]
Scientists Uncover Hidden Blood Pattern in Long COVID
Researchers found persistent microclot and NET structures in Long COVID blood that may explain long-lasting symptoms. Researchers examining Long COVID have identified a structural connection between circulating microclots and neutrophil extracellular traps (NETs). The [...]
This Cellular Trick Helps Cancer Spread, but Could Also Stop It
Groups of normal cbiells can sense far into their surroundings, helping explain cancer cell migration. Understanding this ability could lead to new ways to limit tumor spread. The tale of the princess and the [...]
New mRNA therapy targets drug-resistant pneumonia
Bacteria that multiply on surfaces are a major headache in health care when they gain a foothold on, for example, implants or in catheters. Researchers at Chalmers University of Technology in Sweden have found [...]
Current Heart Health Guidelines Are Failing To Catch a Deadly Genetic Killer
New research reveals that standard screening misses most people with a common inherited cholesterol disorder. A Mayo Clinic study reports that current genetic screening guidelines overlook most people who have familial hypercholesterolemia, an inherited disorder that [...]
Scientists Identify the Evolutionary “Purpose” of Consciousness
Summary: Researchers at Ruhr University Bochum explore why consciousness evolved and why different species developed it in distinct ways. By comparing humans with birds, they show that complex awareness may arise through different neural architectures yet [...]
Novel mRNA therapy curbs antibiotic-resistant infections in preclinical lung models
Researchers at the Icahn School of Medicine at Mount Sinai and collaborators have reported early success with a novel mRNA-based therapy designed to combat antibiotic-resistant bacteria. The findings, published in Nature Biotechnology, show that in [...]
