This article provides an overview of the global nanomedicine market, highlighting key players, emerging technologies, and the challenges and opportunities that influence its growth and commercialization in the healthcare sector.
Nanomedicines are nanotechnology-based drug products developed by combining suitable nanocarriers with active pharmaceutical ingredients (APIs) to treat, diagnose, or prevent various diseases.
The U.S. Food and Drug Administration (FDA) defines nanomedicines as products with at least one dimension in the nanoscale range (1–100 nm) that exhibit distinct chemical, physical, or biological properties compared to larger-scale counterparts.
The nanoscale structure and surface properties of nanomedicines enhance drug solubility, stability, selectivity, targeted delivery, and bioavailability, thereby improving efficacy in treating complex diseases such as cancer, cardiovascular disorders, and neurological conditions.1
Market Overview
The global nanomedicine market, valued at approximately USD 189.55 billion in 2023, is projected to exceed USD 562.95 billion by 2033, reflecting a compound annual growth rate (CAGR) of 11.5 % from 2024 to 2033.2
This growth is driven by advancements in nano-pharmaceuticals and the increasing demand for more effective treatments for cancer, immune system diseases, nervous system disorders, and infectious diseases like AIDS.
A significant trend in this sector is the focus on personalized medicine, where nano-pharmaceuticals facilitate tailored therapies based on individual genetic profiles. This approach improves treatment outcomes through targeted drug delivery, reducing side effects.
For instance, nanomedicines like Doxil and Abraxane have enhanced efficacy in cancer treatment by selectively targeting cancer cells, minimizing damage to healthy tissues, and lowering toxic side effects.
With over 500 active clinical trials involving nanoparticles and more than 100 FDA-approved nanomedicines, the sector is attracting significant investment from major pharmaceutical companies.3
Key Players in the Nanomedicine Market
Several companies and research institutions are at the forefront of nanomedicine development, driving healthcare innovation through new therapies and diagnostics.
Bristol-Myers Squibb
As one of the world’s largest pharmaceutical companies, Bristol Myers Squibb actively develops nanotechnology-based drug delivery systems. It is a leading patent filer in drug delivery nanoparticles, with a focus on oncology, immunology, hematology, and fibrotic diseases.
The company’s use of liposomes to enhance drug targeting, particularly in cancer treatment, has resulted in innovative formulations like Abraxane, which uses nanoparticle-bound albumin for treating metastatic breast cancer.4,5
Moderna
Moderna, a pioneer in mRNA therapeutics, gained global recognition for developing the COVID-19 mRNA vaccine. Its innovative use of lipid nanoparticles to encapsulate mRNA represents a significant advancement in nanomedicine, providing a framework for future therapies targeting various infectious diseases and cancers.6
Nanobiotix
Nanobiotix, a late-stage clinical biotechnology firm based in France, specializes in developing nanotechnology-based treatments for cancer. Its flagship product, NBTXR3, enhances radiotherapy by increasing radiation absorption in tumor cells, improving treatment outcomes with minimal side effects. It is undergoing clinical trials for non-small cell lung and head and neck cancer.7
Generation Bio
Generation Bio is another key player focusing on genetic medicines. Its proprietary cell-targeted lipid nanoparticle (ctLNP) technology enables selective targeting of therapeutic agents to specific tissues while minimizing off-target effects. This innovative approach has significant potential for in vivo cell therapies, such as reprogramming T cells within the patient’s body.8
Jazz Pharmaceuticals
Jazz Pharmaceuticals is a global biopharmaceutical specializing in oncology and neuroscience. Its FDA-approved product, Vyxeos™, is a liposomal formulation combining daunorubicin and cytarabine, indicated for treating therapy-related acute myeloid leukemia. This liposomal delivery system enhances the efficacy of cancer treatment while reducing toxicity compared to traditional drug administration.9
Cytiva
Other notable players include Ratiopharm, which markets the nanoparticle-bound albumin product Pazenir for various cancers, and Pacira, known for ZILRETTA, the first non-opioid treatment for osteoarthritis knee pain using extended-release microsphere technology.12,13
Recent Developments in the Nanomedicine Market
The nanomedicine market is evolving through several emerging technologies that are reshaping the future of healthcare.
On-Site Production of Nanomedicines for Real-Time Treatments
One of the most promising areas of development is the on-site production of nanomedicines. A recent study by researchers at the University of Oklahoma explored tools designed for producing nanomedicines, including vaccine formulations, directly at the point of care.
This approach addresses the limitations of centralized facilities, shipping challenges, and extreme cold storage requirements experienced during the COVID-19 pandemic.
The research team utilized components from 3D printers to create a T-mixer device that facilitates mixing fluid streams containing nanomedicine building blocks and their payloads.
This innovative system not only enhances the accessibility and efficiency of nanomedicine production but can also revolutionize personalized medicine by enabling real-time production of tailored treatments, ultimately improving patient outcomes and reducing the logistical complexities associated with traditional manufacturing processes.14
World’s First Regulatory Guidelines to Accelerate Clinical Translation
While technological advancements are crucial in nanomedicine, standardized frameworks are equally important for improving development and efficacy.
For example, despite recent successes with chemotherapy and vaccine-based nanomedicines, particularly lipid nanoparticles used in mRNA vaccines during the COVID-19 pandemic, clinical translation remains limited relative to research volume.
To address this, a global team of experts established “the DELIVER guidelines,” the world’s first research quality standards designed to reduce costs and accelerate the development of advanced nanomedicine treatments.
These guidelines offer recommendations across various phases, including design, experimentation, manufacturing, preclinical, clinical, regulatory, and business stages, thus maximizing clinical translation potential.
The DELIVER framework will provide essential principles for researchers, clinicians, and regulatory bodies to navigate translational challenges and minimize delays, facilitating personalized therapies tailored to individual patient needs and offering renewed hope for innovative medical solutions.15,16
Challenges in the Nanomedicine Market
The nanomedicine market faces significant challenges that hinder the transition from research to clinical applications.
Despite extensive studies on nanoformulations, only a small fraction progress to market assessments, with even fewer receiving final approval; reports indicate that less than 10 % of basic scientific research successfully translates into clinical applications. This gap, often referred to as the “valley of death,” makes the shift from laboratory to market costly and time-consuming, ultimately increasing healthcare expenses.
Several factors contribute to these challenges. The discrepancy between the in vivo and in vitro behavior of nanoparticles complicates understanding their clinical effectiveness. Tumor complexity and heterogeneity also hinder nanoformulation efficacy, as different tumors display varying gene expression profiles and drug resistance. Moreover, the multifaceted nature of some formulations adds complexity to the approval process, impeding the advancement of nanomedicines to market.
The threat of failure is significant in this landscape, as exemplified by BIND Therapeutics Inc., which declared bankruptcy in 2013 after its promising anticancer nanomedicine, BIND-014, failed to demonstrate efficacy in larger clinical trials despite initial success.
Opportunities for Growth and Development
Despite these challenges, opportunities for growth and development exist in the nanomedicine sector. The market for nanopharmaceuticals is anticipated to advance over the next five years, driven by innovations in bionanotechnology and nanoengineering. Key drivers for development include the establishment of clearer guidelines for nanotechnology-based drugs, increased government funding, and stronger collaboration between startups and established pharmaceutical companies.
To unlock the full potential of nanomedicines, stakeholders must advocate for adaptable intellectual property and regulatory frameworks tailored to the sector’s unique needs. Additionally, prioritizing long-term strategic planning over short-term gains will be essential for navigating the complexities of the nanomedicine landscape and ensuring successful market integration.17
References and Further Reading
- Shan, X., Gong, X., Li, J., Wen, J., Li, Y., Zhang, Z. (2022). Current approaches of nanomedicines in the market and various stage of clinical translation. Acta pharmaceutica Sinica. B. https://doi.org/10.1016/j.apsb.2022.02.025
- Precedence Research. (2024). Nanomedicine Market Size, Share, and Trends 2024 to 2034. [Online] Precedence Research. Available at: https://www.precedenceresearch.com/nanomedicine-market
- Liu, Q., Zou, J., Chen, Z., He, W., Wu, W. (2023). Current research trends of nanomedicines. Acta Pharmaceutica Sinica. https://doi.org/10.1016/j.apsb.2023.05.018
- Global Data. (2024). Leading innovators in drug delivery nanoparticles for the pharmaceutical industry. [Online] Pharmaceutical Technology. Available at: https://www.pharmaceutical-technology.com/data-insights/innovators-iot-nanoparticles-for-drug-delivery-pharmaceutical/
- Bristol-Myers Squibb. (2021). It’s not all smiles in drug development. [Online] Bristol-Myers Squibb. Available at: https://www.bms.com/life-and-science/science/unusual-liposome-image-during-drug-development.html
- Huang, X., Kong, N., Zhang, X., Cao, Y., Langer, R., Tao, W. (2022). The landscape of mRNA nanomedicine. Nature Medicine. https://doi.org/10.1038/s41591-022-02061-1
- Nanobiotix. (2024). A new standard in radiation oncology. [Online] Nanobiotix. Available at: https://nanobiotix.com/pipeline/
- Generation Bio. (2024). It’s time to unlock the full potential of genetic medicine. [Online] Generation Bio. Available at: https://generationbio.com/our-science
- Jazz Pharmaceuticals. (2022). Understanding treatment with VYXEOS, an advancementa,b in secondary AML therapy. [Online] Jazz Pharmaceuticals. Available at: https://vyxeos.com/
- Cytiva. (2024). NanoAssemblr™ commercial formulation system. [Online] Cytiva. Available at: https://www.cytivalifesciences.com/en/us/shop/lipid-nanoparticle-instruments-and-reagents/nanoparticle-formulation-systems/nanoassemblr-commercial-formulation-system-p-45337?srsltid=AfmBOopKpeQb_v_sVLMmejpjM2IYsBz–Qi79zKTKzDvPPr9L6WDwCgH
- Cytiva. (2024). Unleash The Potential Of RNA-LNPS Together. [Online] Cytiva. Available at: https://www.precisionnanosystems.com/
- European Medicines Agency. (2024). Pazenir. [Online] EMA. Available at: https://www.ema.europa.eu/en/medicines/human/EPAR/pazenir
- Pacira Pharmaceuticals. (2024). A non-opioid option for significant extended relief of OA knee pain. [Online] Pacira Pharmaceuticals. https://www.pacira.com/products/zilretta
- Young, H., He, Y., Joo, B., Ferguson, S., Demko, A., Butterfield, SK., Lowe, J., Mjema, NF., Sheth, V., Whitehead, L., Ruiz-Echevarria, MJ., Wilhelm, S. (2024). Toward the Scalable, Rapid, Reproducible, and Cost-Effective Synthesis of Personalized Nanomedicines at the Point of Care. Nano letters. https://doi.org/10.1021/acs.nanolett.3c04171
- Mansfield, A. (2024). Global experts help nanomedicines DELIVER on healthcare promise. [Online]. The University of South Australia. Available at: https://www.unisa.edu.au/media-centre/Releases/2024/global-experts-help-nanomedicines-deliver-on-healthcare-promise/
- Joyce, P., et al. (2024). A translational framework to DELIVER nanomedicines to the clinic. Nature Nanotechnology. https://doi.org/10.1038/s41565-024-01754-7
- Farjadian, F., Ghasemi, A., Gohari, O., Roointan, A., Karimi, M., Hamblin, MR. (2019). Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities. Nanomedicine. https://doi.org/10.2217/nnm-2018-0120
News
Nanocrystals Carrying Radioisotopes Offer New Hope for Cancer Treatment
The Science Scientists have developed tiny nanocrystal particles made up of isotopes of the elements lanthanum, vanadium, and oxygen for use in treating cancer. These crystals are smaller than many microbes and can carry isotopes of [...]
New Once-a-Week Shot Promises Life-Changing Relief for Parkinson’s Patients
A once-a-week shot from Australian scientists could spare people with Parkinson’s the grind of taking pills several times a day. The tiny, biodegradable gel sits under the skin and releases steady doses of two [...]
Weekly injectable drug offers hope for Parkinson’s patients
A new weekly injectable drug could transform the lives of more than eight million people living with Parkinson's disease, potentially replacing the need for multiple daily tablets. Scientists from the University of South Australia [...]
Most Plastic in the Ocean Is Invisible—And Deadly
Nanoplastics—particles smaller than a human hair—can pass through cell walls and enter the food web. New research suggest 27 million metric tons of nanoplastics are spread across just the top layer of the North [...]
Repurposed drugs could calm the immune system’s response to nanomedicine
An international study led by researchers at the University of Colorado Anschutz Medical Campus has identified a promising strategy to enhance the safety of nanomedicines, advanced therapies often used in cancer and vaccine treatments, [...]
Nano-Enhanced Hydrogel Strategies for Cartilage Repair
A recent article in Engineering describes the development of a protein-based nanocomposite hydrogel designed to deliver two therapeutic agents—dexamethasone (Dex) and kartogenin (KGN)—to support cartilage repair. The hydrogel is engineered to modulate immune responses and promote [...]
New Cancer Drug Blocks Tumors Without Debilitating Side Effects
A new drug targets RAS-PI3Kα pathways without harmful side effects. It was developed using high-performance computing and AI. A new cancer drug candidate, developed through a collaboration between Lawrence Livermore National Laboratory (LLNL), BridgeBio Oncology [...]
Scientists Are Pretty Close to Replicating the First Thing That Ever Lived
For 400 million years, a leading hypothesis claims, Earth was an “RNA World,” meaning that life must’ve first replicated from RNA before the arrival of proteins and DNA. Unfortunately, scientists have failed to find [...]
Why ‘Peniaphobia’ Is Exploding Among Young People (And Why We Should Be Concerned)
An insidious illness is taking hold among a growing proportion of young people. Little known to the general public, peniaphobia—the fear of becoming poor—is gaining ground among teens and young adults. Discover the causes [...]
Team finds flawed data in recent study relevant to coronavirus antiviral development
The COVID pandemic illustrated how urgently we need antiviral medications capable of treating coronavirus infections. To aid this effort, researchers quickly homed in on part of SARS-CoV-2's molecular structure known as the NiRAN domain—an [...]
Drug-Coated Neural Implants Reduce Immune Rejection
Summary: A new study shows that coating neural prosthetic implants with the anti-inflammatory drug dexamethasone helps reduce the body’s immune response and scar tissue formation. This strategy enhances the long-term performance and stability of electrodes [...]
Scientists discover cancer-fighting bacteria that ‘soak up’ forever chemicals in the body
A family of healthy bacteria may help 'soak up' toxic forever chemicals in the body, warding off their cancerous effects. Forever chemicals, also known as PFAS (per- and polyfluoroalkyl substances), are toxic chemicals that [...]
Johns Hopkins Researchers Uncover a New Way To Kill Cancer Cells
A new study reveals that blocking ribosomal RNA production rewires cancer cell behavior and could help treat genetically unstable tumors. Researchers at the Johns Hopkins Kimmel Cancer Center and the Department of Radiation Oncology and Molecular [...]
AI matches doctors in mapping lung tumors for radiation therapy
In radiation therapy, precision can save lives. Oncologists must carefully map the size and location of a tumor before delivering high-dose radiation to destroy cancer cells while sparing healthy tissue. But this process, called [...]
Scientists Finally “See” Key Protein That Controls Inflammation
Researchers used advanced microscopy to uncover important protein structures. For the first time, two important protein structures in the human body are being visualized, thanks in part to cutting-edge technology at the University of [...]
AI tool detects 9 types of dementia from a single brain scan
Mayo Clinic researchers have developed a new artificial intelligence (AI) tool that helps clinicians identify brain activity patterns linked to nine types of dementia, including Alzheimer's disease, using a single, widely available scan—a transformative [...]
