Matt Fitzgerald used to bike up and down 3,500 feet through the Santa Ana Mountains on three-hour rides just for fun. Now, nine months after being infected with SARS-CoV-2, the virus that causes Covid-19, he can’t muster walking on flat surfaces for 20 minutes without days of exhaustion.
“My long Covid life remains terrifying,” he told me. “Last weekend I washed my car, dried it, put it back in the garage. Then I got violently sick, could hardly get up to get food. I was unable to read or even call my mom. I’m a shell of myself. But my physical issues aren’t half as bad as my brain problems. It’s hard to describe. You can say brain fog, but that doesn’t come close to doing it justice.”
Another patient of mine, Barbara Nivens, was forced into early retirement as a result of long Covid. Four months after recovering from a mild case of Covid-19, “My memory began to fade,” she told me. “I struggled cognitively as a manager and then HR came after me.”
It’s no wonder that depression and PTSD rates are up in people living with long Covid. There are no approved therapies for the physical or cognitive disabilities that now plague 65 million people around the world, a conservative estimate given the degree of undocumented cases. It is now clear from U.S. and U.K. investigations of approximately 2,000 previously hospitalized Covid patients that six months later more than half have problems managing finances and paying bills as well as completing everyday activities like preparing meals, bathing, getting dressed, or walking across a room.
But what exactly is going on inside the brains of these people from a biological and pathological perspective?
Autopsy studies show that the virus can persist in some people for many months even though they have no symptoms and test negative for the virus. Brains donated by people who died of Covid-19 also show widespread problems in the cells lining the blood vessels and exaggerated clotting, supporting the idea of Covid-19 as a blood flow disorder that brings on brain disease.
Perhaps the most harrowing thing I have done in 30 years as a physician-scientist has been to ask family members I’d never met, often in the middle of the night via telephone during the height of the Covid surges, if I and my colleagues could study their loved one’s brain. In a study we conducted of 20 of these priceless brain donations, we found brain swelling due to decreased blood flow and heightened activity in microglial cells, the so-called white matter in brains that support the neurons that transmit thoughts and help store information. We saw this even in young previously healthy individuals.
A study from the National Institutes of Health of 44 complete autopsies mapped and quantified the distribution of SARS-CoV-2 and showed it was widely distributed throughout the body, including in the hypothalamus and cerebellum in the brain and neurons in the spinal cord. Especially relevant to long Covid, viral fragments were detected in some of the brains of people who died many months after symptom onset.
Evidence that the virus can persist in some people has inspired the design of multiple long Covid treatment trials with Paxlovid. The authors of the NIH autopsy study concluded: “Here we provide the most comprehensive analysis to date of cellular tropism, quantification & persistence of SARS-CoV-2 across the human body including the brain.”
Tropism? That is when cells are involuntarily directed by a stimulus, like a virus, to turn and march in a new, potentially pathological direction. Could it be that instead of returning to a healthy state, the brains of people with long Covid have been redirected toward a type of premature aging or senescence?
In their own words
Nivens, who retired from retail management at age 59, has been diagnosed by her neurologist as having rapid onset dementia due to Covid-19. An incredibly thorough medical work-up found no plausible causes for this dementia other than its onset following her Covid infection, which she contracted before the vaccine was available.
Fitzgerald, age 26, is a mechanical engineer who worked for Tesla and now designs surgical devices — when he can. Since recovering from his initial bout with Covid-19, he’s developed a condition characteristic of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) known as post-exertional malaise, which is why even slight exertion leaves him and millions like him inexplicably incapacitated.
Here’s how they describe their lives today:
Barbara Nivens
“I walk down the hall and see dozens of pictures of family trips and feel like a ghost because I don’t remember any of them. Now I’m trying to figure out who Barbara 2.0 is going to be.” (Her husband, tearing up as he listened to her, said softly, “I just want my wife back.”)
To help rebuild her memory, Nivens does brain exercises including the Color Bee game. “It’ll tell you, for the bee to go in ‘Click on all the green leaves.’ And then I’ll find myself clicking on the orange and the yellow instead of the green, and then I kill my bee, and you only get three bees.
“We were doing puzzles, so I put one in the den and sometimes just to find one piece it would take me 45 minutes to an hour. Because I would think I would know what I was looking for, and then all of a sudden, I forget. It makes me think I’m crazy.”
Matt Fitzgerald
“I feel like I’m underwater. When you talk to me, I can hear you, but my brain does not understand the words. I can’t comprehend what you’re saying. I have no intellectual capacity or energy to digest data.
“At work my brain is just begging for rest. I struggle with finding words and completing tasks in a timely manner. It’s the worst. I’ll be in a meeting and know exactly what I want to say before I say it. I’ll start saying it and I’ll get to a word, and I just cannot think of the word. I’ll just be like, ‘Give me a moment,’ and I’ll go through my brain cycling through words. This week it was consistent. I couldn’t think of the word consistent. I kept thinking it was coincident or concentric or constant.”
“I used to build prototypes multiple days a week and now, if I do anything in the lab, I’m pretty much wiped out for a week. It’s terrifying. I mean, I’ve had to dig real deep. How much longer will I feel like this? I’m scared.”
Lifting the stigma
Such problems in executive function, memory, and processing speed are what many people complain about in the long Covid support groups colleagues and I developed and provide weekly for free to Long Covid survivors from around the country as part of the Critical Illness, Brain Dysfunction, and Survivorship Center at Vanderbilt University Medical Center and the Nashville VA Medical Center.
Science validates their injuries. A picture is emerging from animal models showing how ongoing inflammation of glial cells disrupts the electrical conduction highways in the brain’s white matter that link to and support the neurons in gray matter. It’s as if the bridges (white matter) linking different territories of the brain have been blown up and the land itself (nerves in the cerebral cortex and hippocampus) become scorched, leaving people with long Covid plagued by thinking and memory deficits.
An MRI study from George Washington University of people who’d had mild Covid-19 symptoms several months earlier found much less gray matter in their brains than they should have had. This ominous finding complements a large controlled study conducted as part of the U.K. Biobank showing that, as compared to people who had never tested positive for SARS-CoV-2, a loss of actual brain tissue was seen in the olfactory cortex and limbic system — think impaired smell, emotions, and memory formation — among people with long Covid.
This tracks with PET scan studies of people with long Covid showing impaired cellular metabolism in the frontal lobe six months following acute Covid. Other long Covid studies using PET scans correlate this slower metabolism with numerous functional problems and symptoms — ongoing issues with smell, memory, cognitive abilities, chronic pain, and sleep disruption — that harms quality of life.
Long Covid is now considered to be a disability by the U.S. Department of Health and Human Services, but the reality is that most people have great difficulty qualifying to receive financial resources. They feel left behind and too often find themselves jobless.
As they wait for results from ongoing and future clinical trials, Nivens, Fitzgerald, and others like them focus on cognitive rehabilitation using brain exercises like crossword puzzles, Bananagrams, and Sudoku. But because of the dicey and unpredictable elements of post-exertional malaise, long Covid patients with ME/CFS must learn the daily art of pacing themselves.
As the public health disaster of long Covid unfolds, everyone can play a part. We can validate the suffering of people who are all too often stigmatized and disbelieved even by medical professionals. We can help friends and loved ones find their voices as the experts of their own illness. And, most of all, we need to start talking more about long Covid as the emergency it is for those living with it, for the leaders of families who now feel like they are failing those who depend on them, for the work force, and beyond.
On a personal level, every American can take steps to reduce the likelihood of getting Covid, or long Covid. A study of 440,000 people with a single Covid infection, 40,000 with multiple infections, and 5 million controls who never had Covid found more death and long Covid after multiple Covid infections. If advised by your physician, get the new bivalent vaccine and wear masks in indoor public spaces such as theaters and airplanes.
News
Antibody engineering drives innovation in drug development
Monoclonal antibodies (mAbs) are used to prevent, detect, and treat a broad spectrum of non-communicable and communicable diseases. Over the past few years, the market for mAbs has grown exponentially with an expected compound [...]
Breakthrough Study Reveals How Bladder Cancer Starts and Spreads
Researchers found that DNA mutations from antiviral enzymes and chemotherapy fuel early bladder cancer, while abnormal circular DNA in tumor cells drives resistance to therapy. These discoveries open new therapeutic avenues. A groundbreaking study led by [...]
AI and Quantum Mechanics Accelerate Drug Discovery
A recent article published in the Journal of Chemical Information and Modeling researchers at Southern Methodist University (SMU) have developed SmartCADD, an open-source virtual tool designed to speed [...]
Targeting ‘undruggable’ diseases: Researchers reveal new levels of detail in targeted protein degradation
Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called protein degraders which can be deployed to combat what have previously been regarded as "undruggable" diseases, [...]
Revolutionizing Virology: AI Discovers Over 160,000 New RNA Viruses
Largest discovery of new virus species sheds light on the hidden virosphere. Artificial intelligence (AI) has been used to reveal details of a diverse and fundamental branch of life living right under our feet and in every [...]
Cardiac Crisis: COVID-19 Doubles Risk of Heart Attacks, Strokes, and Death
Research indicates that COVID-19 survivors face doubled risks of severe cardiac events for years after recovery, especially if hospitalized. People with A, B, or AB blood types are particularly vulnerable, highlighting the need for personalized approaches [...]
AI steps into science limelight with Nobel wins
For long periods of its history, artificial intelligence has lurked in the hinterland of science, often unloved and unfunded—but two Nobel prizes in one week suggest its time in the sunshine has finally arrived. [...]
MIT Scientists Shed New Light on the Critical Brain Connections That Define Consciousness
A new study provides further evidence that consciousness depends on communication between the brain’s sensory and cognitive regions in the cortex. Our brains are constantly making predictions about our surroundings, enabling us to focus [...]
Common Chemicals Found in Shampoo and Plastic Could Be Quietly Disrupting Your Heart’s Rhythm
UC study of Fernald data links environmental phenols to heart toxicities Environmental phenols are present in numerous everyday consumer products, serving as preservatives in packaged foods, parabens in shampoos, and bisphenol A (BPA) in [...]
Revolutionary Brain Tech Offers New Hope for Stroke and Injury Recovery
University of Pittsburgh researchers report that deep brain stimulation (DBS) can effectively enhance motor functions in individuals with arm and hand paralysis due to brain injuries, with promising results from early human and monkey [...]
NIH Scientists Discover Gene Responsible for Rare Eye Disease
Findings supported by the NIH pave the way for the development of genetic testing, clinical trials, and therapies. Researchers at the National Institutes of Health (NIH) and their collaborators have discovered a gene linked to certain [...]
Alzheimer’s Breakthrough: Synthetic THC Pill Proves Effective in Clinical Trial
Patients tolerated synthetic THC (dronabinol) well, without the adverse effects commonly associated with existing Alzheimer’s agitation medications. A study conducted by researchers from Johns Hopkins University School of Medicine and Tufts University School of Medicine found that a pill form [...]
The Future of Rare Disease Treatment with Precision Medicine
Understanding rare diseases Rare diseases affect less than 5 people out of 10,000. However, this still amounts to about 7% of the world’s population, with over 10,000 such conditions. Almost all are genetic in [...]
Doctors issue warning for upcoming ‘tripledemic
The term ‘tripledemic’ has hit headlines this week as the NHS begins its Covid and fluvaccine roll-out for vulnerable adults. As the cold weather sets in, many of us have experienced a decline in health, and this may [...]
The FDA approved a gel that can stop bleeding from wounds in seconds
Aug 15 (Reuters) - The U.S. Food and Drug Administration has cleared Cresilon's gel to quickly control bleeding, the privately held company said on Thursday, potentially giving emergency medical technicians and combat medics a [...]
High levels of microplastics found in prostate tumors, possibly linked to take-out food
The presence of microplastics in prostate tumors points to potential health risks, and researchers are calling for urgent studies to explore how take-out food may be driving this exposure. In a recent study published [...]