Melissa, a 30-year-old educator, came to the emergency department with a sudden onset of double vision. She had not been in an accident or suffered any trauma and had never experienced this symptom before. However, she noted that a few months earlier, the vision in one of her eyes had become blurred and then returned to normal shortly after. She told herself it was a sign of fatigue after a period of intense work on a screen.
After some basic optometric tests, then more advanced tests of visual perception, the visual episodes were thought to be related to multiple sclerosis. Melissa was then referred to a neuro-ophthalmology specialist who confirmed the diagnosis, and she was quickly treated.
Is Melissa’s case unique? Over my 30 years working as an optometrist, I’ve seen many patients with different vision and eye health problems, the cause of which turned out to be an illness they didn’t know they had.
As a professor at the School of Optometry at the Université de Montréal, I teach students that certain ocular symptoms can be linked to general health problems. Optometrists are trained to identify the various diseases that can manifest themselves through the eyes and to work with other health professionals to manage them.
Diabetes
Because diabetes will affect almost 8% of the population by 2030, screening is a crucial issue. However, it is estimated that diabetes is not generally diagnosed until six to 13 years after its onset. An eye health examination can shorten this delay since it is often possible to identify characteristic lesions of the disease at the back of the eye before other symptoms of diabetes appear.
Early diagnosis is crucial since within five years of diagnosis (i.e., 11 to 15 years after the onset of diabetes), 25% of patients with Type 1 (juvenile diabetes) and 40% of those with Type 2 (adult diabetes) who are treated with insulin will develop eye lesions that can have a major effect on their vision. Early identification and rigorous monitoring of eye health significantly reduces the risk of blindness, which can happen when the disease is not treated.
Unmasking the silent killer
If diabetes affects a significant number of patients without them knowing it, what can be said about high blood pressure and high cholesterol? These two conditions significantly increase the risk of coronary heart disease or stroke in our societies.
The eye is the only place in the human body where blood vessels can be seen without having to make an incision or use invasive techniques.
- High blood pressure (known as the silent killer) can be seen by crushing of vessels and very specific signs on the retina.
- Hypercholesterolemia creates cholesterol deposits inside the vessels.
- Atherosclerosis is associated with Hollenhorst plaques, also visible inside the vessels.
- Cholesterol can also be seen in the cornea (lipid arc) or in the adnexa (xanthelasma).
In all these cases, very often the symptoms experienced by the patient are so few, or progress so slowly, that he or she considers them almost normal.
Normotensive or open-angle glaucoma
The absence of symptoms is also the norm for glaucoma. This pathology of the optic nerve is usually associated with excessive production of aqueous humor in the eye or a deficit in its evacuation.
The pressure inside the eye then increases and through different mechanisms leads to the loss of nerve fibers in the nerve. The visual field narrows very slowly (and therefore can go unnoticed), so the person ends up with tunnel vision after several years.
By the time this loss of vision affects them, it is often late, so the damage to the optic nerve can be very extensive. This damage is mainly ocular, although it can also be induced by the effect of certain drugs (such as cortisone).
Normotensive glaucoma is of a completely different nature. In this case, the pressure inside the eye remains normal but the nerve is still damaged. The mechanisms at play are different from those in chronic open-angle glaucoma.
Normotensive glaucoma is often associated with low blood pressure or conditions such as sleep apnea. If it is present, the patient must be referred to a family doctor for a thorough investigation.
The disease of the century
Because cancer is becoming so widespread and is expressed in so many ways, we call it the disease of the century. Cancers that affect the eye (retinoblastoma) can also cause metastases to the lungs and liver.
Here again, the disease often develops without symptoms until it is too late. So early detection is crucial, because the patient’s very survival is at stake.
Other types of asymptomatic retinal pigment (shaped like a bear’s paw) may be associated with cancer of the colon, which has a very negative prognosis if management is delayed.
A simple visual field measurement may reveal abnormalities that some patients are unaware of, or that they consider so benign they don’t bother to report them. However, many visual field abnormalities hide brain tumors, such as pituitary adenoma, or nerve fibers compressed by blood vessels.
Abnormal eye movements, asymmetric pupillary responses, sudden reading problems or the appearance of diplopia are all yellow flags that require further ocular and neurological investigation.
Rather than the mirror of the soul, the eyes become an open window on our overall health. That makes regular consultations with an optometrist more important than ever, even when there are no symptoms. Many disorders can be detected and treated to either minimize illnesses or prevent them altogether.
This article is republished from The Conversation under a Creative Commons license. Read the original article.
 
News
Researchers propose five key questions for effective adoption of AI in clinical practice
While Artificial Intelligence (AI) can be a powerful tool that physicians can use to help diagnose their patients and has great potential to improve accuracy, efficiency and patient safety, it has its drawbacks. It [...]
Advancements and clinical translation of intelligent nanodrugs for breast cancer treatment
A comprehensive review in "Biofunct. Mater." meticulously details the most recent advancements and clinical translation of intelligent nanodrugs for breast cancer treatment. This paper presents an exhaustive overview of subtype-specific nanostrategies, the clinical benefits [...]
It’s Not “All in Your Head”: Scientists Develop Revolutionary Blood Test for Chronic Fatigue Syndrome
A 96% accurate blood test for ME/CFS could transform diagnosis and pave the way for future long COVID detection. Researchers from the University of East Anglia and Oxford Biodynamics have created a highly accurate [...]
How Far Can the Body Go? Scientists Find the Ultimate Limit of Human Endurance
Even the most elite endurance athletes can’t outrun biology. A new study finds that humans hit a metabolic ceiling at about 2.5 times their resting energy burn. When ultra-runners take on races that last [...]
World’s Rivers “Overdosing” on Human Antibiotics, Study Finds
Researchers estimate that approximately 8,500 tons of antibiotics enter river systems each year after passing through the human body and wastewater treatment processes. Rivers spanning millions of kilometers across the globe are contaminated with [...]
Yale Scientists Solve a Century-Old Brain Wave Mystery
Yale scientists traced gamma brain waves to thalamus-cortex interactions. The discovery could reveal how brain rhythms shape perception and disease. For more than a century, scientists have observed rhythmic waves of synchronized neuronal activity [...]
Can introducing peanuts early prevent allergies? Real-world data confirms it helps
New evidence from a large U.S. primary care network shows that early peanut introduction, endorsed in 2015 and 2017 guidelines, was followed by a marked decline in clinician-diagnosed peanut and overall food allergies among [...]
Nanoparticle blueprints reveal path to smarter medicines
Lipid nanoparticles (LNPs) are the delivery vehicles of modern medicine, carrying cancer drugs, gene therapies and vaccines into cells. Until recently, many scientists assumed that all LNPs followed more or less the same blueprint, [...]
How nanomedicine and AI are teaming up to tackle neurodegenerative diseases
When I first realized the scale of the challenge posed by neurodegenerative diseases, such as Alzheimer's, Parkinson's disease and amyotrophic lateral sclerosis (ALS), I felt simultaneously humbled and motivated. These disorders are not caused [...]
Self-Organizing Light Could Transform Computing and Communications
USC engineers have demonstrated a new kind of optical device that lets light organize its own route using the principles of thermodynamics. Instead of relying on switches or digital control, the light finds its own [...]
Groundbreaking New Way of Measuring Blood Pressure Could Save Thousands of Lives
A new method that improves the accuracy of interpreting blood pressure measurements taken at the ankle could be vital for individuals who are unable to have their blood pressure measured on the arm. A newly developed [...]
Scientist tackles key roadblock for AI in drug discovery
The drug development pipeline is a costly and lengthy process. Identifying high-quality "hit" compounds—those with high potency, selectivity, and favorable metabolic properties—at the earliest stages is important for reducing cost and accelerating the path [...]
Nanoplastics with environmental coatings can sneak past the skin’s defenses
Plastic is ubiquitous in the modern world, and it's notorious for taking a long time to completely break down in the environment - if it ever does. But even without breaking down completely, plastic [...]
Chernobyl scientists discover black fungus feeding on deadly radiation
It looks pretty sinister, but it might actually be incredibly helpful When reactor number four in Chernobyl exploded, it triggered the worst nuclear disaster in history, one which the surrounding area still has not [...]
Long COVID Is Taking A Silent Toll On Mental Health, Here’s What Experts Say
Months after recovering from COVID-19, many people continue to feel unwell. They speak of exhaustion that doesn’t fade, difficulty breathing, or an unsettling mental haze. What’s becoming increasingly clear is that recovery from the [...]
Study Delivers Cancer Drugs Directly to the Tumor Nucleus
A new peptide-based nanotube treatment sneaks chemo into drug-resistant cancer cells, providing a unique workaround to one of oncology’s toughest hurdles. CiQUS researchers have developed a novel molecular strategy that allows a chemotherapy drug to [...]
 
									
















 
	 
	 
	 
	